Results 221 to 230 of about 1,392,331 (344)

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells. [PDF]

Aging Cell, 2019
Ogrodnik M, Salmonowicz H, Gladyshev VN.
europepmc   +1 more source

Serum d-serine accumulation after proximal renal tubular damage involves neutral amino acid transporter Asc-1 [PDF]

, 2019
Masataka Suzuki, Yusuke Gonda, Marina Yamada, Arno Vandebroek, Masashi Mita, Kenji Hamase, Masato Yasui, Jumpei Sasabe   +7 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Damage Accumulation Modeling and Rate Dependency of Spinal Dura Mater. [PDF]

J Eng Sci Med Diagn Ther, 2018
Ramo N, Shetye SS, Puttlitz CM.
europepmc   +1 more source

Retraction: “Atomistic simulation of damage accumulation and amorphization in Ge” [J. Appl. Phys. 117, 055703 (2015)] [PDF]

, 2017
Jose L. Gomez-Selles, A. Claverie, B. Sklénard, F. Bénistant, Ignacio Martin‐Bragado   +4 more
openalex   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Prediction of Damage Accumulation Effect of Wood Structural Members under Long-Term Service: A Machine Learning Approach. [PDF]

Materials (Basel), 2019
Li Z, Tao D, Li M, Shu Z, Jing S, He M, Qi P.   +6 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Study on Damage Accumulation and Life Prediction with Loads below Fatigue Limit Based on a Modified Nonlinear Model. [PDF]

Materials (Basel), 2018
Zhang J, Fu X, Lin J, Liu Z, Liu N, Wu B.   +5 more
europepmc   +1 more source