Results 41 to 50 of about 406,322 (263)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Nondestructive Characterization of Damaged Bonds

, 1993
This paper presents a new technique to characterize the damage of a bonded component. The theoretical analysis models a damaged bond as a random distribution of small interphase cracks and cavities. Interaction of ultrasonic waves with these interfacial cracks are studied by a differential self-consistent scheme (DSS) in conjunction with the ...
Jacobs, Laurence, Qu, Jianmin
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Main controlling factors and characterization of overburden fracture damage based on energy conduction mechanism

Meitan xuebao
The migration and fracture of overlying strata during coal seam mining is an important factor affecting the strata behaviors in working face. By studying the damage and failure characteristics of overlying strata from the perspective of energy, the ...
Cun ZHANG, Baiqiang FAN, Zhaopeng REN, Jianqi MA, Yixin ZHAO, Quansheng LI, Yongqiang ZHAO   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A review on the application of neutron and high-energy X-ray diffraction characterization methods in engineering materials

工程科学学报, 2022
As powerful techniques for multidisciplinary research, the neutron and synchrotron radiation sources have the advantages of deep penetration and high brilliance, providing advanced and powerful tools for characterizing microstructures and revealing ...
Yan-dong WANG, Run-guang LI, Zhi-hua NIE, Shi-lei LI   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Characterization of eucalyptus clones subject to wind damage [PDF]

Pesquisa Agropecuária Brasileira, 2017
: The objective of this work was to test a new methodology to assess the resistance of trees to wind damage and determine the characteristics that increase clone resistance to winds.
Antônio José Vinha Zanuncio, Amélia Guimarães Carvalho, Angélica de Cassia Oliveira Carneiro, Paulina Valenzuela, William Gacitúa, Fernando Palha Leite, Jorge Luiz Colodette   +6 more
doaj   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source