Results 131 to 140 of about 852,434 (310)

The Identification of Criteria and Indicators to Evaluate Hazardous Street Trees: A Delphi Study. [PDF]

, 2002
Trees have been playing an important roles in our lives for centuries, however too often we are unaware of the risk associated with the trees. Trees with defects may become hazard and cause personal injury or property damage. Structural defects such as
Maruthaveeran, Sreetheran
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Impact pathway analysis for research planning: the case of aquatic resources research in the WorldFish Center [PDF]

, 2004
In line with its mandate of poverty reduction and sustainable development, the WorldFish Center is orienting its research towards high impact scientific activity.
Acosta, B.O., Ahmed, M., Briones, M., Dey, M.M., Prein, M., Stobutzki, I.   +5 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Development of a management tool for the equal evaluation of economic, social and ecological effects of adaptation scenarios for attenuating the effects of climate change induced flooding [PDF]

, 2008
Climate change is expected to influence river flooding which may have important implications for socio-economic and ecological systems. Changed flood risks require a proper policy. Water managers need to develop and select those adaptation scenarios that
De Smet, L, De Sutter, Renaat
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Experimental and numerical simulation study on mechanical behavior and microscopic damage characteristics of sandstone under triaxial compression

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
Exploring the mechanical behavior of deep rocks, determining the development laws of microcracks, and enriching the evaluation indicators of rock damage are prerequisites for ensuring the safety and stability of underground engineering. In this research,
Jing Yang, Guang-Jian Liu, Zong-long Mu, Wen-ling Tian, Bo-wen Sun   +4 more
doaj   +1 more source

Smart EMI monitoring of thin composite structures [PDF]

, 2011
This paper presents a structural health monitoring (SHM) method for in-situ damage detection and localization in carbon fibre reinforced plates (CFRP).
Cherrier, Olivier, Lachaud, Frédéric, Morlier, Joseph, Pommier-Budinger, Valérie, Selva, Pierre   +4 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source