Results 61 to 70 of about 6,461,546 (275)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Applied Sciences, 2018 Understanding the tensile failure mechanisms in carbon fiber woven composites based on the acoustic emission (AE) technique is a challenging task.
Wei Zhou, Peng-fei Zhang, Yan-nan Zhang
doaj +1 more source
Mechanisms of Brain Damage in Twins [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1982 SUMMARY:The brains of 18 twins dying in the perinatal period showed a variety of lesions. Eleven had subependymal cell plate hemorrhage which had ruptured into the lateral ventricles in five. Five had periventricular damage. Three had anoxic neuronal damage. One acardiac monster had bilateral cerebral infarction.
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
MECHANISM OF ALCOHOLIC TESTICULAR DAMAGE
The Japanese Journal of Urology, 1992 To observe the mechanism of alcoholic testicular damage, in a previous experiment we used weanling male SD rats aged 45 days, weighing about 200 g, and fed a liquid diet (Lieber's) containing 5% ethanol. The latter accounted for 36% of total caloric intake for 7 weeks, but did not result in testicular atrophy.
Shirai, Takashi, Ikemoto, Isao
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Geomatics, Natural Hazards & RiskIn underground mining, common issues include surface subsidence and tailings accumulation. To address these issues, the layered tailings cemented filling technique is frequently utilized.
Pengyu Wang +4 more
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Effect of hygrothermal environment on mechanical properties and damage mechanism of CFRP
Cailiao gongcheng, 2019 The moisture absorption properties of carbon fiber reinforced plastics (CFRP) laminates treated with three kinds of hygrothermal environments (relative humidity 85% RH, temperature 25, 70, 85℃ respectively) were investigated by accelerated moisture ...
YANG Xu-dong +3 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source