Results 171 to 180 of about 1,333,549 (315)

Damage mechanism investigation on fiber reinforced recycled cement aggregate concrete in a cold region. [PDF]

Sci Rep
Li W, Li Z, Xu W, Ji Y.
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Pitting damage levels estimation for planetary gear sets based on model simulation and grey relational analysis

, 2011
The planetary gearbox is a critical mechanism in helicopter transmission systems. Tooth failures in planetary gear sets will cause great risk to helicopter operations.
Gu, Fengshou, Hu, Niaoqing, Cheng, Zhe, Qin, Guojun   +3 more
core  

Macro-Meso Characteristics and Damage Mechanism of Cement-Stabilized Macadam Under Freeze-Thaw Cycles and Scouring. [PDF]

Materials (Basel)
Liu H, Zhou S, Kuang A, Jin D, Peng X, Lv S.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Study on the acoustic emission characteristics and damage mechanism of power batteries under electrical load. [PDF]

PLoS One
Jin P, Xu X, Xu J, Yang S, Yan W, Miao H, Sun S.   +6 more
europepmc   +1 more source

Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke. [PDF]

Cell Biosci, 2023
Gao HM, Chen H, Cui GY, Hu JX.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Progressive damage mechanism of rock-anchoring interface under cyclic impact loading. [PDF]

Sci Rep
Wang P, Zhang N, Kan J, Xie Z, Cui G, Guo F, Cao C, Xiang Z, Han C.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source