Results 231 to 240 of about 1,100,188 (302)

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

IoT enabled offshore infrastructure management and its impact on monitoring maintenance safety compliance and structural resilience. [PDF]

Sci Rep
Alsehaimi A, Alsulami BT, Ghani MU, Al-Aidrous AMH, Baarimah AO, Ramu MB.   +5 more
europepmc   +1 more source

Composite materials for marine applications – key challenges for the future

, 2008
Blake, J.I.R., Boyd, S.W., Dulieu-Barton, J.M., Quinn, S., Shenoi, R.A.   +4 more
core  

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Adverse events in different administration routes of Edaravone: A pharmacovigilance study based on the FDA adverse event reporting system. [PDF]

PLoS One
Ge D, Wu L, Yang J, Sun J, Wang J, Wang J, Song H, Wei R, Xu Z, Zhao B, Sun R, Wang Y.   +11 more
europepmc   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Introducing FMEA plus method for comprehensive safety risk assessment in the steel industry. [PDF]

PLoS One
Soltanzadeh A, Zarei E, Mahdinia M, Hosseinzadeh K, Sadeghi-Yarandi M.   +4 more
europepmc   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

BANTAM-01: A Multicenter, Open-Label, First-in-Human Phase 1 Dose Escalation and Expansion Study of ²²⁵Ac-GPC3 (BAY 3547926) in Patients with Advanced Hepatocellular Carcinoma. [PDF]

J Nucl Med
Tjeertes J, Dostalek M, Glaus C, Gupta V, Li D, Nestler A, Pelekanou V, Pinkert J, Ratih I, Smith E, Subramanyam S, Vogel A, Walker K, Wilson Woods A, Zimmermann S, Junger H.   +15 more
europepmc   +1 more source