Results 181 to 190 of about 1,571,262 (350)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Post-transcriptional regulation of DNA Damage Binding protein 2 and the identification of a novel mRNA stability determinant

, 2010
Brian D. Melanson
openalex   +1 more source

Metabolic drivers of genome instability in cancer: mechanisms and therapeutic opportunities. [PDF]

Exp Hematol Oncol
Wang YS, Qian LH, Liu CC, Yu KD.
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The Stability and Behavior of Cr-Rich α' Precipitates Under Cascade Damage In Fe-15Cr-8Al Ternary Alloys: An Atomic-Scale Simulation Study

, 2022
Xichuan Liao, Yangchun Chen, Hengfeng Gong, Tong Liu, Huiqiu Deng, Wangyu Hu, Fei Gao   +6 more
openalex   +1 more source

Macro-Meso Damage Mechanism of Sandstone Under Wet-Dry Cycles: A Study Based on Nuclear Magnetic Resonance Technology. [PDF]

Materials (Basel)
Wei Y, Niu F, Zhu S, Zhang J.
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide [PDF]

, 2019
Bong-Kyeong Oh, Yoojung Choi, Jaeman Bae, Won Moo Lee, Jeong‐Kyu Hoh, Joong Sub Choi   +5 more
openalex   +1 more source

Role of CHD4 in tumor progression, DNA damage response and treatment resistance (Review). [PDF]

Oncol Rep
Li S, Ma Q, Lian K, Jiang Z, Ma Y.
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source