A Closer Look at Penetration: The Efficacy Gap in Vitamin C Products. [PDF]
Maloney ME, Hall M, Kononov T, Zahr A.
europepmc +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Long Term Stability of A Single Crystal Ni-Base Superalloy Coated with Damage Cure Coating Alloy
Mazaku Okazaki +3 more
openalex +1 more source
Composite Heterogeneity Threshold (CHT) in CNT- and Oxide-Modified Woven Glass/Epoxy Composites Under Multi-Loading Conditions: Experimental Validation and Continuum Model Assessment. [PDF]
Çetin B, Dahil L.
europepmc +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Synergistic Effects of Ceria Morphology in Magnetically-Assisted Chemical Mechanical Polishing: A Dual-Component Approach for Ultraprecision Surface Planarization. [PDF]
Wang H +6 more
europepmc +1 more source
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Interaction of CSN4 to DDB1 regulates its stability and function in DNA damage signaling. [PDF]
Choi SH, Cho K, Kim ES, Yoo HY.
europepmc +1 more source

