Results 111 to 120 of about 3,378,493 (310)

Developments in impact damage modeling for laminated composite structures [PDF]

open access: yes
Damage tolerance is the most critical technical issue for composite fuselage structures studied in the Advanced Technology Composite Aircraft Structures (ATCAS) program.
Avery, William B.   +3 more
core   +1 more source

Taming the Floods: Using an Intellectual History of Chinese Hydraulic Thought to Address Contemporary Issues in China’s Water Governance [PDF]

open access: yes, 2018
China’s current hydraulic systems are in a state of atrophy, caused by sustained damage over centuries to infrastructure that has changed very little. Added to an already weak infrastructure is a relatively new crisis of water scarcity, which is forcing ...
Danison, Sophia Rose
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

A constitutive model with damage for high temperature superalloys [PDF]

open access: yes
A unified constitutive model is searched for that is applicable for high temperature superalloys used in modern gas turbines. Two unified inelastic state variable constitutive models were evaluated for use with the damage parameter proposed by Kachanov ...
Sherwood, J. A., Stouffer, D. C.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Chronic exposure to environmental concentrations of 6PPDQ induces neurotoxicity via perturbing multiple neurotransmission pathways in zebrafish

open access: yesEnvironment International
Previous research has demonstrated acute toxicity of 6PPD-quinone (6PPDQ), the ozonation product of tire-manufacturing additive 6PPD; however, chronic effects on aquatic organisms under real-world conditions remain unclear.
Chuan Yi   +7 more
doaj   +1 more source

Flood damage, vulnerability and risk perception - challenges for flood damage research [PDF]

open access: yes
The current state-of-the-art in flood damage analysis mainly focuses on the economic evaluation of tangible flood effects. It is contended in this discussion paper that important economic, social and ecological aspects of flood-related vulnerabilities ...
Messner, Frank, Meyer, Volker
core  

Which role do excited states play in radiation damage to organic solid-state compounds? [PDF]

open access: yes, 2010
Ionizing radiation induces radicals in organic materials. When such species are created in biological macromolecules like DNA, they harm living organisms. This detrimental effect is explicitly exploited for the sterilisation of e.g.
Aalbergsjø, Siv G.   +6 more
core   +1 more source

Breakdown of disordered media by surface loads

open access: yes, 2004
We model an interface layer connecting two parts of a solid body by N parallel elastic springs connecting two rigid blocks. We load the system by a shear force acting on the top side.
A. R. Massih   +8 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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