Results 171 to 180 of about 12,996,719 (308)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Persistent Gaps in the Ultimate Mechanisms of Antimicrobial-Induced Bacterial Killing. [PDF]

Antibiotics (Basel)
Nath A, Rodríguez-Rojas A.
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage. [PDF]

Elife
Huang Z, Luo S, Wang Z, Zhang Z, Jiang B, Nie Q, Zhang J.   +6 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Mechanism of bolt rib geometry in controlling the brittle-to-ductile failure transition of bolt-grout interfaces. [PDF]

Sci Rep
Bian W, Yang J, Lu X, He X, Wang K, Zhang C, Yang X, Lei Y, Zhang R, Huang L.   +9 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Proceedings of the 5th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2017

Journal of Translational Medicine, 2017
Ryan Leone, Katie J. Jensen, Claire Abijay, Troy Dolmetsch, Natalie Koons, Daniel N. Darlington, Andrew P. Cap, Xiaowu Wu, Christopher P. Delavan, Maryanne C. Herzig, Barbara A. Christy, Kelley M. Kempski, August N. Blackburn, Robert A. De Lorenzo, Megan B. Blackburn, Matthew C. Donald, Harold G. Klemcke, Brenna K. Harrington, Celestine J. He, Belinda I. Gómez, Tony Chao, Joshua S. Little, Tiffany C. Heard, Michael A. Dubick, David M. Burmeister, Amy Xu, Kerfoot Walker III, Arezoo Mohammadipoor, Luis Rodriguez, Teryn Roberts, Andriy Batchinsky, Leopoldo Cancio, Ben Antebi, Ryan A. Walford, Colby S. McIntosh, Grantham C. Peltier, Umang Sharma, Robbie K. Montgomery, Michael A. Meledeo, James A. Bynum, Sarah Lovelace, Larry Estlack, Katherine Jensen, Lexi Kazen, Lee C. Mangum, Gerardo R. Garcia, Kevin S. Akers   +46 more
doaj   +1 more source

Models for Saturation Damage State and Interfacial Shear Strengths in Multilayer Coatings

, 2010
Y. Leterrier, J. H. Waller, J. Månson, J. Nairn   +3 more
semanticscholar   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source