Results 191 to 200 of about 3,378,493 (310)

Investigation on Mechanical Properties, Damage Forms, and Failure Mechanisms of Additively Manufactured Schoen Gyroid TPMS Porous Structures Under Compressive Load. [PDF]

Materials (Basel)
Hou Y, Cai X, Zhang W, Liu B, Mu Z, Wang J, Han L, Xie W, Sun H.   +8 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Validation of proposals for definitions of moderate and severe disease activity in SLE: impact on flares, quality of life, damage accrual, hospitalisations and mortality. [PDF]

Lupus Sci Med
Altabás-González I, Rua-Figueroa I, Roberts K, Mamani IL, Mouriño C, Martinez-Barrio J, Galindo Izquierdo M, Calvo-Alén J, Erausquin C, Serrano-Benavente B, Uriarte E, Tomero E, Freire-González M, Blanco R, Salgado E, Gómez-Sabater S, Fernandez-Nebro A, Sangüesa C, Narvaez J, Mena Vázquez N, Menor-Almagro R, Rosas Gómez de Salazar JC, Aurrecoechea E, Ibarguengoitia-Barrena O, Montilla C, Bonilla G, Segarra VT, Juan-Mas A, García-Villanueva MJ, Morales CM, Horcada L, Lozano-Rivas N, Iñiguez C, Arevalo M, Paredes B, Exposito L, Toyos FJ, Flores-Fernandez E, Nóvoa Medina J, Fragio Gil JJ, Bohórquez C, Pego-Reigosa JM.   +41 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Photooxidative molecular damage under blue light. [PDF]

Exp Mol Med
Kim E, Kim S, Kim M, Min D.
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Nonlinear creep constitutive model of rock under water and force conditions. [PDF]

Sci Rep
Peng GC, Zhu ZG, An JJ, Xu HH, Zhu T.
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Molecular Basis of Persister Awakening and Lag-Phase Recovery in <i>Escherichia coli</i> After Antibiotic Exposure. [PDF]

Int J Mol Sci
Stojowska-Swędrzyńska K, Laskowska E, Kuczyńska-Wiśnik D.   +2 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source