Results 191 to 200 of about 2,533,177 (315)

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang   +8 more
wiley   +1 more source

Correction: Next‑Generation SCS Programming Platform: Enhancing ECAP Fidelity and Objectivity to Improve Patient Experience. [PDF]

open access: yesPain Ther
Parker DJ   +12 more
europepmc   +1 more source

A Folded, Structure‐Integrated Bimodal Sensor Enabling Non‐Contact and Tactile Perception for Intelligent Robots

open access: yesAdvanced Science, EarlyView.
A foldable bimodal sensor integrates a triboelectric nanogenerator and graphene piezoresistive effect into a monolithic laser‐induced graphene film. It enables synchronous non‐contact and tactile perception, achieving a distance of 110 mm, a sensitivity of 11.2 kPa−1, and a response time of 10 ms.
Weixiong Yang   +10 more
wiley   +1 more source

Correction: Heat shock factor-1 alleviates ER-stress in Caenorhabditis elegans. [PDF]

open access: yesSci Rep
Ahmed S   +12 more
europepmc   +1 more source

Extra Climate Benefits From Afforestation Due to Reduced Forest Fragmentation in China

open access: yesAdvanced Science, EarlyView.
Afforestation in China reduced forest fragmentation in 2015, transforming 51.8 M ha of edge forests into interior forests. This enhanced carbon sequestration (1.4±0.2 Pg CO2e, a cooling biogeochemical effect), while reduced albedo (−0.9 Pg CO2e, a warming biophysical effect) partially offset the gain, yielding a net extra climate benefit of ...
Nan Meng   +19 more
wiley   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

open access: yesAdvanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo   +4 more
wiley   +1 more source

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