Results 31 to 40 of about 642,992 (266)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Hijo del hombre, hijos de la mujer y maestros de la ley. Rasgos escatológicos de las Bienaventuranzas del Evangelio, con una bibliografía selecta sobre el «Hijo del Hombre»

Estudios Eclesiásticos, 2018
La expresión «Hijo de Hombre» que se halla en los evangelios canónicos ha recibido interpretaciones diferentes en la exégesis bíblica. El presente trabajo defiende la hipótesis de que «Hijo de Hombre» en Lc 6,22c hace referencia a Dn 7,13, e investiga ...
Pino Di Luccio
doaj  

Genetic and phenotypic diversity of native potatoes (Solanum spp.) from the Central Andes of Peru

Acta Agronómica
The diversity of native potatoes cultivated above 3500 masl in the Pasco region (Central Andes of Peru) has not been fully characterized. It is currently subject to constant genetic erosion caused by biotic and abiotic factors.
Edith Luz Zevallos Arias, Josué Hernán Inga Ortíz, Karina Jessica Marmolejo Gutarra, Fernando James Álvarez Rodríguez, Rocio Karim Paitan Gilian, Gina Haydi Rixi Vilca, Dante Alex Becerra Pozo, Edgar Lidio Neyra Valdez   +7 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

EL BIOHUERTO: RECURSO DIDÁCTICO EN EL APRENDIZAJE DE LA COMUNICACIÓN EN EDUCACIÓN BÁSICA REGULAR PRIMARIA / THE BIO-GARDEN: A DIDACTIC RESOURCE FOR COMMUNICATION LEARNING IN REGULAR BASIC PRIMARY EDUCATION

Pedagogía y Sociedad, 2021
Introducción: La investigación forma parte del proyecto “El biohuerto como ecosistema artificial para preservar la biodiversidad, el medio ambiente, la seguridad alimentaria y el desarrollo de competencias en las instituciones de Educación Básica Regular”
Javier Raúl Minaya Lovatón , Dionicio López Basilio , Raúl Malpartida Lovatón   +2 more
doaj  

Carcinoma renal con cuadro clínico de infección urinaria recurrente en paciente joven

Anales de la Facultad de Medicina, 2019
El cáncer renal es una neoplasia con una tasa de incidencia de 4,4% por 100 000 habitantes a nivel mundial; el carcinoma de células renales representa el 90% de los tumores renales malignos.
Roy R. Vasquez-Sullca, Alfredo D. Balcazar-Reyes, Herman Yalta-Arce, Luis A. Allemant-Mori   +3 more
doaj   +1 more source

Comparación de dos textos de la tradición oral peruana con la genética textual

Investigación Valdizana, 2022
El presente artículo tiene como objetivo comparar dos textos de la tradición oral peruana, los cuentos “El caldo de sapo y “El condenado de Vicco”, narraciones pertenecientes a la provincia de Pasco, para ello se analizó ambos textos con la genética o ...
Pablo L. LaMadrid-Vivar, Teófilo F. Valentín-Melgarejo   +1 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source