Results 31 to 40 of about 2,533,177 (315)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

modo de las comunicaciones divinas a los Profetas

Estudios Eclesiásticos, 1945
El presente trabajo se propone dar cuenta de la realidad interna o externa de las comunicaciones divinas a los profetas. Si para los patriarcas, para Moisés, no tienen dificultad en señalar las revelaciones externas, para los profetas escritores son de ...
Rafael Criado
doaj  

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

EL BIOHUERTO: RECURSO DIDÁCTICO EN EL APRENDIZAJE DE LA COMUNICACIÓN EN EDUCACIÓN BÁSICA REGULAR PRIMARIA / THE BIO-GARDEN: A DIDACTIC RESOURCE FOR COMMUNICATION LEARNING IN REGULAR BASIC PRIMARY EDUCATION

Pedagogía y Sociedad, 2021
Introducción: La investigación forma parte del proyecto “El biohuerto como ecosistema artificial para preservar la biodiversidad, el medio ambiente, la seguridad alimentaria y el desarrollo de competencias en las instituciones de Educación Básica Regular”
Javier Raúl Minaya Lovatón , Dionicio López Basilio , Raúl Malpartida Lovatón   +2 more
doaj  

Carcinoma renal con cuadro clínico de infección urinaria recurrente en paciente joven

Anales de la Facultad de Medicina, 2019
El cáncer renal es una neoplasia con una tasa de incidencia de 4,4% por 100 000 habitantes a nivel mundial; el carcinoma de células renales representa el 90% de los tumores renales malignos.
Roy R. Vasquez-Sullca, Alfredo D. Balcazar-Reyes, Herman Yalta-Arce, Luis A. Allemant-Mori   +3 more
doaj   +1 more source

Comparación de dos textos de la tradición oral peruana con la genética textual

Investigación Valdizana, 2022
El presente artículo tiene como objetivo comparar dos textos de la tradición oral peruana, los cuentos “El caldo de sapo y “El condenado de Vicco”, narraciones pertenecientes a la provincia de Pasco, para ello se analizó ambos textos con la genética o ...
Pablo L. LaMadrid-Vivar, Teófilo F. Valentín-Melgarejo   +1 more
doaj   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Translation Talks: getting to know Daniel Hahn

, 2020
Daniel Hahn is a writer, editor and translator with about 70 books to his name. His translations from Portuguese, Spanish and French include fiction and non-fiction for adults and children, from Europe, Africa and the Americas.
Hahn, Daniel
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