Results 11 to 20 of about 37,152 (207)

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Advantages of the zebrafish (Danio rerio) model in solving contemporary problems of neurotoxicity, teratotoxicity and genotoxicity of xenobiotics [PDF]

Farmacja Polska, 2023
The zebrafish (Danio rerio), a small fish belonging to the Cyprinidae family, is one of the most popular animal models used in laboratory studies, including toxicology.
Magdalena Czuma, Agnieszka Kozioł, Maciej Tadeusz Gawlik   +2 more
doaj   +1 more source

Haematopoiesis in Zebrafish (Danio Rerio)

Frontiers in Immunology, 2022
Haematopoiesis in fish and mammals is a complex process, and many aspects regarding its model and the differentiation of haematopoietic stem cells (HSCs) still remain enigmatic despite advanced studies.
Michał Stosik, Beata Tokarz-Deptuła, Wiesław Deptuła   +2 more
doaj   +1 more source

New Insights into the Toxicokinetics of 3,4-Dichloroaniline in Early Life Stages of Zebrafish (Danio rerio)

Toxics, 2020
In the fish embryo toxicity (FET) test with zebrafish (Danio rerio) embryos, 3,4-dichloroaniline (3,4-DCA) is often employed as a positive control substance [...]
Sabrina Schiwy, Ann-Kathrin Herber, Henner Hollert, Markus Brinkmann   +3 more
doaj   +1 more source

Сравнительная оценка эффектов анксиолитиков бензодиазепинового и небензодиазепинового рядов у Danio rerio

Российские биомедицинские исследования
Актуальность. Одной из наиболее перспективных моделей для проведения исследований функций головного мозга в норме и при патологии является Danio rerio. Ранее у Danio rerio показано центральное действие анксиолитиков бензодиазенинового ряда.
Виктор Андреевич Лебедев, Сарнг Саналович Пюрвеев, Александр Сергеевич Девяшин, Татьяна Евгеньевна Лебедева, Евгений Рудольфович Бычков, Андрей Юрьевич Юров, Иван Андреевич Балаганский, Андрей Андреевич Лебедев, Петр Дмитриевич Шабанов   +8 more
doaj   +1 more source

Effects of Subchronic Exposure of Diclofenac on Growth, Histopathological Changes, and Oxidative Stress in Zebrafish (Danio rerio)

The Scientific World Journal, 2014
The aim of this study was to investigate effects of subchronic exposure to sublethal levels of diclofenac on growth, oxidative stress, and histopathological changes in Danio rerio. The juvenile growth tests were performed on Danio rerio according to OECD
Eva Praskova, Lucie Plhalova, Lucie Chromcova, Stanislava Stepanova, Iveta Bedanova, Jana Blahova, Martin Hostovsky, Misa Skoric, Petr Maršálek, Eva Voslarova, Zdenka Svobodova   +10 more
doaj   +1 more source

Cadmium and visual performance in Danio rerio

Journal of Biological Research, 2013
This study describes the negative effects exerted by cadminum intoxication on behavioral responses to re-illumination with white or colored light in the zebrafish, Danio rerio.
C.M. Motta, P. Simoniello
doaj   +1 more source

Experimental model for assessing the effectiveness of radioprotectors in biomedical research

Acta Biomedica Scientifica
Background. Radiobiological research on chemical radioprotectors is relevant in the study of radiation injuries and in practical medicine during radiation therapy of cancer patients.
N. N. Omelchuk, Yu. G. Simakov, L. V. Volkova, V. I. Popadyuk, O. V. Anisimova, T. N. Khilko, O. E. Chernova   +6 more
doaj   +1 more source

A comparative analysis of transcription factor expression during metazoan embryonic development. [PDF]

PLoS ONE, 2013
During embryonic development, a complex organism is formed from a single starting cell. These processes of growth and differentiation are driven by large transcriptional changes, which are following the expression and activity of transcription factors ...
Alicia N Schep, Boris Adryan
doaj   +1 more source

Sex blind: bridging the gap between drug exposure and sex-related gene expression in Danio rerio using next-generation sequencing (NGS) data and a literature review to find the missing links in pharmaceutical and environmental toxicology studies

Frontiers in Toxicology, 2023
The sex of both humans and Danio rerio has previously been shown to affect the way individuals respond to drug exposure. Genes which allow identification of sex in juvenile zebrafish show potential to reveal these confounding variables between sex in ...
Alex C. King, Armin K. Zenker
doaj   +1 more source