Results 131 to 140 of about 791,604 (307)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Healthy lifestyle and life expectancy with and without major chronic disease – a cohort study

Scientific Reports
Health behaviors affect life expectancy, but whether disease is present can greatly impact both the individual and society. How health behavior is reflected in the utilization of health care services is yet to be investigated to support the impact of ...
Anne Kirstine Eriksen, Kathrine Grell, Peter Fjeldstad Hendriksen, Jan Wohlfahrt, Anne Tjønneland, Anja Olsen   +5 more
doaj   +1 more source

Patterns of errors and weaknesses in the diagnostic process: retrospective analysis of malpractice claims and adverse events from two national databases

BMJ Open Quality
Background Diagnostic errors (DEs) are a significant global patient safety issue, often associated with increased morbidity and mortality due to overlooked, delayed, or incorrect diagnoses.
Kim Lyngby Mikkelsen, Charlotte Frendved, Siri Tribler, Eva Benfeldt, Rikke Mørch Jørgensen   +4 more
doaj   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

The Causal Relationship between Foreign Direct Investment and Current Account: An Empirical Investigation for Pakistan Economy [PDF]

This paper investigates relationship between FDI and current account (CA) in Pakistan using the Johansen-Juselius cointegration technique and the Granger causality test.
Ahmad, Mohsin Hasnain, Siddiqui, Danish Ahmed   +1 more
core   +1 more source

An Increasing Misalignment Between Crop Distribution and Environmental Resources Under Climate Change in China

Advanced Science, EarlyView.
Climate change reshapes the spatial alignment between crop production and environmental resources. Using multi‐source data and a crop model, integrated climatic, water, and soil endowments for maize and wheat are quantified and compared with harvest distributions.
Zheng'e Su, Zhentao Zhang, Jin Zhao, Xia Liang, Chuang Zhao, Zhijuan Liu, Minghao Zhuang, Jing Sun, Bo Lu, Ke Liu, Johannes W. M. Pullens, Matthew T. Harrison, Deli Chen, Xiaoguang Yang   +13 more
wiley   +1 more source

Coupled Above‐ and Belowground Ecosystem Stability Worldwide

Advanced Science, EarlyView.
Are the worlds above and below our feet in sync? This global exploration reveals an entangled fate between above‐ and belowground ecosystem stability. It identifies arid regions as hotspots for this coupling and highlights temperature stability as a vital safeguard for maintaining ecosystem balance across our warming planet.
Zexin Meng, Huiwen Li, Yiping Wu, Peter B. Reich, Nico Eisenhauer, Diego Abalos, Daniel Revillini, Shuguang Liu, Wende Yan, Ji Chen, Alexey Voinov, Zhifeng Yang, Ying‐Ping Wang, Fubo Zhao, Linjing Qiu, Jingfeng Xiao, Shantao An, Guopeng Liang, Manuel Delgado‐Baquerizo   +18 more
wiley   +1 more source

L’art danois au xixe siècle : autour de l’« École de Copenhague »

Perspective, 2011
Regine Gerhardt
doaj   +1 more source

Institutionalized Social Technologies Index: A Global Perspective [PDF]

This paper presents an index of institutionalized social technologies covering its two main dimensions namely Risk reducing technologies and Anti Rent seeking technologies and in turn covers several social, institutional, political and economic aspects ...
Ahmed, Qazi Masood, Siddiqui, Danish Ahmed   +1 more
core   +1 more source