Results 31 to 40 of about 896,449 (354)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Danish Research Libraries – Danish Models
LIBER Quarterly: The Journal of the Association of European Research Libraries, 2000 In Europe we tend to think of cultural diversity as the very essence of our European fabric. This conference has also underlined the necessity for sticking to internationally recognised standards if we want a seamless cooperation in the future. So I believe that presenting the Danish situation to you serves a dual purpose: that of confirming that ...
openaire +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
European Journal of Psychotraumatology, 2021 Background: While empirical support for the ICD-11 distinction between posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) is growing, empirical research into the ICD-11 model of CPTSD in military populations is scarce and inconsistent ...
Sofie Folke +2 more
doaj +1 more source
The 2011 Debacle over Danish Border Control: A Mismatch of Domestic and European Games. EU Diplomacy Paper 01/2012, January 2012 [PDF]
, 2012 In May 2011 the Danish minority government successfully obtained the support of the Danish People’s Party to carry out a comprehensive pension reform. In return, it was agreed that Denmark would reintroduce border controls.
Munkoe, Malthe
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Why Danish Organic Farming Policy has been Successful [PDF]
, 2010 The Danish organic farming policy has proved successful in growing the market for organic food. This article outlines the architecture of the policy and explains why, unlike elsewhere, it has put considerable emphasis on demand creating measures ...
Daugbjerg, Carsten
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Better Baltic Sea wave forecasts: improving resolution or introducing ensembles? [PDF]
Ocean Science, 2018 The performance of short-range operational forecasts of significant wave height (SWH) in the Baltic Sea is evaluated. Forecasts produced by a base configuration are intercompared with forecasts from two improved configurations: one with improved ...
T. Schmith +3 more
doaj +1 more source