Results 231 to 240 of about 132,524 (284)

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Novel Urokinase-Type Plasminogen Activator Receptor-Targeting Optical Imaging Agent ICG-Glu-Glu-AE105 for Visualization of Malignant Glioma During Surgery: First-in-Human Study in 35 Patients with Brain Cancer. [PDF]

Neurosurgery
Skjøth-Rasmussen J, Azam A, Juhl K, Ginsborg S, Kryspin Sørensen M, Sølling C, Larsen CC, Winther Kristensen B, Scheie D, Kjaer A, Kjaer A.   +10 more
europepmc   +1 more source

Early shift to oral antibiotic treatment for pyogenic vertebral osteomyelitis (SAVE): study protocol for an open label, non-inferiority, nation-wide randomized controlled clinical trial. [PDF]

Trials
Theilgaard ZP, Weis N, Ravn P, Bernhard PH, Jørgensen NP, Knudsen JA, Öbrink-Hansen K, Ørsted I, Schønning K, Johansen IS, Lebech AM.   +10 more
europepmc   +1 more source

One‐Dimensional Polycyclic Aromatic Hydrocarbons Incorporating Multiple Dithiafulvene Units—Novel Multi‐Redox and Electrochromic Systems

Angewandte Chemie, EarlyView.
Planar polycyclic aromatic hydrocarbons (PAHs) incorporating three or four dithiafulvene (DTF) units were synthesized via Horner–Wadsworth–Emmons reactions to create large π‐conjugated redox‐active frameworks. These molecules display strong intermolecular associations and distinct odd–even redox behavior, enabling formation of mixed‐valence and radical‐
Cecilie Rindom, Florim Seljmani, Lukas Bradley Woodcock, Mogens Brøndsted Nielsen   +3 more
wiley   +1 more source

Efficacy of Cryoneurolysis on Chronic Pain in Patients with Knee Osteoarthritis: A Double-blinded Randomized Controlled Sham Trial. [PDF]

Anesthesiology
Nygaard NB, Koch-Jensen C, Vaegter HB, Wedderkopp N, Blichfeldt-Eckhardt M, Gram B.   +5 more
europepmc   +1 more source

Neuroinflammation and TSPO-Targeted Imaging Before and After Meningioma Surgery

Brain and Spine
Dr. Jeppe Haslund-Vinding, PhD Claus Svarer, Dr, PhD Andrea Daniela Maier, Dr. Nadja Blum, PhD Frederik Vilhardt, Josefine Lange, Josephine Budde, Signe Moldrup, Dr, DMSc Lars Pinborg, Dr, PhD Morten Ziebell, Dr, Dr.Phil Torstein Meling, Gerda Krog Thomsen, Dr, PhD Per Jensen, PhD Brice Ozenne, Dr, DMSc Gitte Moos Knudsen, Dr. Chair, DMSc Tiit Mathiesen   +15 more
doaj   +1 more source