Results 131 to 140 of about 1,465,941 (244)
The Impact of Foregrounds on Dark Ages Measurements with the Highly Redshifted 21 cm Line
The Astrophysical JournalStudies of the cosmic dark ages (30 ≲ z ≲ 150) using the highly redshifted 21 cm line of neutral hydrogen offer unparalleled amounts of cosmological information, and recent years have seen the refinement of concepts for such experiments (e.g., CoDEX ...
Jonathan C. Pober, Willow Smith
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem +9 more
wiley +1 more source
Recovering 21cm Monopole Signals Without Smoothness
The Open Journal of AstrophysicsWe expect the monopole signal at the lowest frequencies below $100\,$MHz to be composed to two components: the deep Rayleigh-Jeans tail of the cosmic microwave background and two distinct features: the dark ages trough at $\sim 17\,$MHz and the cosmic ...
Rugved Pund, Anže Slosar, Aaron Parsons
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin +8 more
wiley +1 more source
Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse +13 more
wiley +1 more source
State and society in the early Middle Ages: the Middle Rhine Valley, 400–1000
, 2006 Book synopsis: This book shows just how much can be discovered about the so-called "Dark Ages," between the fall of Rome and the high Middle Ages. Whereas it is believed widely that the source materials for early medieval Europe are too sparse to allow ...
Innes, Matthew
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno +19 more
wiley +1 more source
Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring
Annals of Clinical and Translational Neurology, EarlyView.The early‐morning surge in false seizure alarms supports exploring time‐ or state‐dependent detection thresholds to reduce false detections. ABSTRACT Seizure detection devices can improve the safety of children with epilepsy, yet high false alarms limit their clinical applicability.
Mohammad Shahbakhti +6 more
wiley +1 more source