Results 111 to 120 of about 43,240 (245)

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

A potential CO2 carrier to improve the utilization of HCO3– by plant-soil ecosystem for carbon sink enhancement

Journal of Advanced Research
Introduction: Improving the rhizospheric HCO3– utilization of plant-soil ecosystem could increase the carbon sink effect of terrestrial ecosystem. However, to avoid its physiological stress on the crop growth, the dosage of HCO3– allowed to add into the ...
Feihong Liang, Shihui Wei, Long Ji, Shuiping Yan   +3 more
doaj   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Phylogenetically and metabolically diverse active carbon-fixing microbes reside in mangrove sediments

Microbiome
Background Mangroves are hotspots of carbon sequestration in transitional zones between marine and terrestrial ecosystems. Microbially driven dark carbon fixation (DCF) is prominent in sediments, yet our understanding of the DCF process across this ...
Shasha Wang, Zhuoming Zhao, Ruolin Cheng, Liang Cui, Jun Wang, Maxim Rubin-Blum, Yao Zhang, Bolin Liu, Xing Chen, Federico Baltar, Xiaxing Cao, Xuezhe Wen, Karine Alain, Zhen Chen, Jing Liao, Lijing Jiang, Zongze Shao   +16 more
doaj   +1 more source

Contribution of ammonia oxidizers to inorganic carbon fixation in the dark ocean

Abstract Ammonia-oxidizing archaea are the most abundant chemolithoautotrophs in the ocean, comprising up to 40% of microbial cells in deep waters, and are assumed to dominate dissolved inorganic carbon (DIC) fixation below the sunlit surface layer.
Barbara Bayer, Katharina Kitzinger, Nicola L. Paul, Justine B. Albers, Mak A. Saito, Michael Wagner, Craig A. Carlson, Alyson E. Santoro   +7 more
openaire   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Metaproteomic analysis decodes trophic interactions of microorganisms in the dark ocean

Nature Communications
Proteins in the open ocean represent a significant source of organic matter, and their profiles reflect the metabolic activities of marine microorganisms.
Zihao Zhao, Chie Amano, Thomas Reinthaler, Federico Baltar, Mónica V. Orellana, Gerhard J. Herndl   +5 more
doaj   +1 more source

Mesoscale feature on mesopelagic dark carbon fixation and carbon budgets

Effects of mesoscale feature on mesopelagic dark carbon fixation and carbon budgets ----
Le Coq, Pauline, Christaki, Urania, van Wambeke, France, Chevillon, Elisabeth, Zakardjian, Bruno, Garel, Marc, Guasco, Sophie, Baumas, Chloé, Dekas, Anne, Bonin, Patricia, Al, Badr, Gesson, Maéva, Le Moigne, Frédéric, Pujo-Pay, Mireille, Crispi, Olivier, Grosso, Olivier, Moutin, Thierry, Bhairy, Nagib, de Saint Léger, Emmanuel, Memery, Laurent, Guidi, Lionel, Armougom, Fabrice, Grossart, Hans-Peter, Tamburini, Christian   +23 more
openaire   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source