Results 51 to 60 of about 526,256 (284)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Density Estimation of Fog in Image Based on Dark Channel Prior

Atmosphere, 2022
This paper proposes a method and an original index for the estimation of fog density using images or videos. The proposed method had the advantages of convenient operation and low costs for applications in automatic driving and environmental monitoring ...
Hong Guo, Xiaochun Wang, Hongjun Li
doaj   +1 more source

The dark matter halo shape of edge-on disk galaxies - II. Modelling the HI observations: methods [PDF]

, 2010
This is the second paper of a series in which we attempt to put constraints on the flattening of dark halos in disk galaxies. For this purpose, we observe the HI in edge-on galaxies, where it is in principle possible to measure the force field in the ...
Boulanger, de Blok, Dickey, Fall, Fraternali, Fraternali, García-Ruiz, J. C. O'Brien, K. C. Freeman, Kregel, Kregel, Lo, Mathewson, Nelder, O'Brien, Olling, P. C. van der Kruit, Petric, Rownd, Rubin, Sancisi, Shane, Shostak, Sofue, Sofue, Swaters, Takamiya, Uson, van der Kruit, van der Kruit, van der Kruit, Warmels   +31 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Removal of fog from hazy images and their restoration

Journal of King Saud University: Engineering Sciences
The prominent reason behind road accidents during the winter season is the presence of fog in the environment. Other important reasons for the degradation of visibility are haze, smog, clouds and rain.
Vidya Nitin More, Vibha Vyas
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Patch-Wise Blind Image Deblurring Via Michelson Channel Prior

IEEE Access, 2019
Motion blur exists in many computer vision tasks, including faces, texts, and low-illumination images etc. It has been proved that Dark Channel Prior (DCP) and Bright Channel Prior (BCP) can both help the image deblurring by enhancing the dark or bright ...
Guoquan Wen, Chao Min, Zeyun Jiang, Zhaozhong Yang, Xiaogang Li   +4 more
doaj   +1 more source

A remote‐sensing image enhancement algorithm based on patch‐wise dark channel prior and histogram equalisation with colour correction

IET Image Processing, 2021
The object identification within an image captured during rough weather conditions (such as haze, fog) poses difficulty due to the reduction of an image. The rough weather conditions lead not only to the variation of the image's visual effect but also to
Fayaz Ali Dharejo, Yuanchun Zhou, Farah Deeba, Munsif Ali Jatoi, Yi Du, Xuezhi Wang   +5 more
doaj   +1 more source

Observation of An Evolving Magnetic Flux Rope Prior To and During A Solar Eruption

, 2012
Explosive energy release is a common phenomenon occurring in magnetized plasma systems ranging from laboratories, Earth's magnetosphere, the solar corona and astrophysical environments.
B Kliem, CJ Schrijver, DE McKenzie, DM Rust, EN Parker, F Yuan, G Aulanier, J Zhang, JR Lemen, KP Dere, L Burlaga, LM Green, M Yamada, O Olmedo, P Kumar, R Liu, RL Moore, RP Lepping, S Zharkov, SE Gibson, SK Antiochos, T Hirayama, TP Intrator, VS Titov, W Daughton, X Cheng   +25 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source