Results 121 to 130 of about 3,411,153 (359)

DARKON FLUID — A MODEL FOR THE DARK SECTOR OF THE UNIVERSE? [PDF]

open access: yesInternational Journal of Geometric Methods in Modern Physics, 2012
We introduce darkons as fluid particles of a Galilean massless self-gravitating fluid. This fluid exhibits anisotropic scaling with [Formula: see text]. The minimal gravitational coupling dynamically generates a gravitational mass density of either sign. Hence such fluid may serve as a model for the dark sector of the Universe.
STICHEL, P. C., ZAKRZEWSKI, WOJTEK J.
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Inhomogeneous viscous dark fluid coupled with dark matter in the FRW universe [PDF]

open access: yes, 2014
A cosmological model with an inhomogeneous viscous dark fluid coupled with dark matter in a flat Friedman-Robertson-Walker universe is investigated. The influence of dark matter on the behavior of an inhomogeneous viscous fluid of this kind, responsible ...
E. Elizalde, V. Obukhov, A. Timoshkin
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Three fluid cosmological model using Lie and Noether symmetries

open access: yes, 2011
We employ a three fluid model in order to construct a cosmological model in the Friedmann Robertson Walker flat spacetime, which contains three types of matter dark energy, dark matter and a perfect fluid with a linear equation of state.
Paliathanasis, Andronikos   +1 more
core   +1 more source

Invariant Solutions and Nonlinear Self-Adjointness of the Two-Component Chaplygin Gas Equation

open access: yesDiscrete Dynamics in Nature and Society, 2019
In this paper, the Lie group method is performed on a special dark fluid, the Chaplygin gas, which describes both dark matter and dark energy in the present universe.
Ben Gao, Yanxia Wang
doaj   +1 more source

Dark Matter from freeze-in and its inhomogeneities

open access: yesJournal of High Energy Physics, 2023
We consider generic freeze-in processes for generation of Dark Matter, together with the consequent re-thermalization of the Standard Model fluid. We find that Dark Matter inherits the Standard Model adiabatic inhomogeneities on the cosmological scales ...
Alessandro Strumia
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Exotic Compact Objects with Two Dark Matter Fluids

open access: yesThe Astrophysical Journal, 2023
The generic properties of compact objects made of two different fluids of dark matter are studied in a scale-invariant approach. We investigate compact objects with a core–shell structure, where the two fluids are separated, and with mixed dark matter ...
Marie Cassing   +3 more
doaj   +1 more source

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