Results 71 to 80 of about 169,400 (221)

In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators

British Journal of Pharmacology, EarlyView.
Background and Purpose Cystic fibrosis (CF) is due to loss‐of‐function variants of the CF transmembrane conductance regulator (CFTR) channel. The most effective treatment for people with CF carrying the F508del mutation is the triple combination of elexacaftor–tezacaftor–ivacaftor (ETI).
Emanuela Pesce, Valeria Tomati, Valeria Capurro, Mariateresa Lena, Cristina Pastorino, Miro Astore, Serdar Kuyucak, Benoit Chevalier, Elvira Sondo, Federico Cresta, Alice Dighero, Vito Terlizzi, Cristina Fevola, Stefano Costa, Maria Cristina Lucanto, Valeria Daccò, Laura Claut, Francesca Ficili, Benedetta Fabrizzi, Renata Bocciardi, Federico Zara, Carlo Castellani, Luis J. V. Galietta, Shafagh A. Waters, Alexandre Hinzpeter, Nicoletta Pedemonte   +25 more
wiley   +1 more source

3.55 keV X-ray line signal from excited dark matter in radiative neutrino model

Physics Letters B, 2014
We study an exciting dark matter scenario in a radiative neutrino model to explain the X-ray line signal at 3.55 keV recently reported by XMN-Newton X-ray observatory using data of various galaxy clusters and Andromeda galaxy.
Hiroshi Okada, Takashi Toma
doaj   +1 more source

A patient‐derived orthotopic xenograft model unveils metastatic dynamics in head and neck squamous cell carcinoma

The FEBS Journal, EarlyView.
Metastasis in head and neck squamous cell carcinoma (HNSC) poses significant clinical challenges. This proof‐of‐concept study establishes patient‐derived orthotopic xenografts (PDOXs) as advanced models that closely replicate primary HNSC tumours, including local lymph node metastasis and the intricate cancer–stroma interaction.
Yuchen Bai, Benjamin Blyth, Jarryd Boath, Qiji Deng, Ruihong Huang, Charbel Darido   +5 more
wiley   +1 more source

Solution of the dark matter riddle within standard model physics: from black holes, galaxies and clusters to cosmology

Frontiers in Astronomy and Space Sciences
It is postulated that the energy density of the (quantum) vacuum acts firstly as dark energy and secondly as a part of dark matter. Assisted by electric fields arising from a small charge mismatch in the cosmic plasma, it can condense on mass ...
Theodorus Maria Nieuwenhuizen
doaj   +1 more source

Two-mediator dark matter models and cosmic electron excess

Journal of High Energy Physics, 2019
The cosmic electron energy spectrum recently observed by the DAMPE experiment exhibits two interesting features, including a break around 0.9 TeV and a sharp resonance near 1.4 TeV.
Xuewen Liu, Zuowei Liu, Yushan Su
doaj   +1 more source

I Would Rather Die: Postcolonial Analysis of Rebellion Speeches in Star Wars: Andor

The Journal of Popular Culture, EarlyView.
ABSTRACT In Star Wars: Andor, the choice for prisoners of Narkina 5 was clear: freedom or death. Two critical speeches from the Narkina 5 prison episodes demonstrate how to disrupt the power of the Empire and the human cost of rebellion. There are parallels between these speeches and the history of rebellion on Earth. This paper will use these speeches
Kristina Vera‐Phillips
wiley   +1 more source

DARK MATTER AND DARK ENERGY IN THE COMA CLUSTER OF GALAXIES

Odessa Astronomical Publications, 2013
The Coma cluster of galaxies is stud­ied as a giant aggregation of dark matter and baryons embedded in the dark energy background. Key theory relations for the local dark-energy effects are given. On the basis of the theory and current observational data,
G. S. Bisnovatyi-Kogan, A. D. Chernin
doaj   +1 more source

Noble gases and nitrogen in material from asteroid Bennu

Meteoritics &Planetary Science, EarlyView.
Abstract We report the elemental and isotopic abundances of all stable noble gases (helium, neon, argon, krypton, and xenon) in eight particles from asteroid Bennu returned by NASA's OSIRIS‐REx mission. We also report nitrogen abundances and isotopic ratios that were analyzed alongside neon and argon in four additional Bennu particles.
B. Marty, L. Zimmermann, E. Füri, D. V. Bekaert, J. J. Barnes, A. N. Nguyen, H. C. Connolly, D. S. Lauretta   +7 more
wiley   +1 more source

The fall of the Haag (LL4‐6) chondrite breccia—Just 8 years after the nearby fall Stubenberg (LL6)

Meteoritics &Planetary Science, EarlyView.
Abstract On October 24, 2024, an impressive fireball was visible over Austria. After the possible strewn field was calculated, the first sample of the Haag meteorite, with a mass of 8.76 g, was discovered on November 2, 2024, 8 days after the fireball event. Four more samples were found afterward putting the total sample mass at about 151 g.
Addi Bischoff, Markus Patzek, Jean‐Alix Barrat, Stig Bartel, Jasper Berndt, Henner Busemann, Tommaso Di Rocco, Mattias Ek, Manuela A. Fehr, Dieter Heinlein, Daniela Krietsch, Björn Lehnert, Colin Maden, Oscar Marchhart, Martin Martschini, Silke Merchel, Andreas Pack, Andrea Patzer, Marie Pichotta, Maximilian P. Reitze, Philippe Schmitt‐Kopplin, Maria Schönbächler, Leon Thannheiser, Iris Weber, Alexander Wieser, Karl Wimmer   +25 more
wiley   +1 more source

Formation of the Dark Matter–Deficient S0 Galaxy NGC 4111 under the Tidal Interactions

The Astrophysical Journal Letters
We present high-sensitivity and large-scale atomic hydrogen (H i ) observations toward lenticular (S0) galaxy NGC 4111 using the Five-hundred-meter Aperture Spherical Radio Telescope.
Mei Ai, Ming Zhu, Nai-ping Yu, Jin-long Xu, Xiao-lan Liu, Yingjie Jing, Qian Jiao, Yao Liu, Chuan-peng Zhang, Jie Wang, Peng Jiang   +10 more
doaj   +1 more source