Results 91 to 100 of about 213,451 (373)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Study of wormhole stability in the framework of black hole surrounded by the pseudo-isothermal dark matter halo

European Physical Journal C: Particles and Fields
This work is devoted to exploring the formation and stability of thin-shell wormholes developed through the two similar copies of black holes bounded by the pseudo-isothermal dark matter halo. It is found that the horizon radius of a black hole decreases
Faisal Javed, Arfa Waseem, Ghulam Fatima, Bander Almutairi   +3 more
doaj   +1 more source

Beyond Collisionless Dark Matter: Particle Physics Dynamics for Dark Matter Halo Structure [PDF]

, 2013
Dark matter (DM) self-interactions have important implications for the formation and evolution of structure, from dwarf galaxies to clusters of galaxies.
S. Tulin, Hai-Bo Yu, K. Zurek
semanticscholar   +1 more source

Galaxy Disruption in a Halo of Dark Matter

Science, 2003
The relics of disrupted satellite galaxies have been found around the Milky Way and Andromeda, but direct evidence of a satellite galaxy in the early stages of disruption has remained elusive. We have discovered a dwarf satellite galaxy in the process of being torn apart by gravitational tidal forces as it merges with a larger galaxy's dark matter halo.
Forbes, Duncan A., Beasley, Michael A., Bekki, Kenji, Brodie, Jean P., Strader, Jay   +4 more
openaire   +5 more sources

Dark matter–radiation interactions: the impact on dark matter haloes [PDF]

Monthly Notices of the Royal Astronomical Society, 2015
Interactions between dark matter (DM) and radiation (photons or neutrinos) in the early Universe suppress density fluctuations on small mass scales. Here we perform a thorough analysis of structure formation in the fully non-linear regime using N-body simulations for models with DM-radiation interactions and compare the results to a traditional ...
Silvia Pascoli, Céline Bœhm, Céline Bœhm, Carlton M. Baugh, Ryan J. Wilkinson, J. A. Schewtschenko   +5 more
openaire   +5 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Halo-Independent Comparison of Direct Dark Matter Detection Data

Advances in High Energy Physics, 2014
We review the halo-independent formalism that allows comparing data from different direct dark matter detection experiments without making assumptions on the properties of the dark matter halo.
Eugenio Del Nobile
doaj   +1 more source

The Dark Matter halo of the Milky Way, AD 2013 [PDF]

, 2013
We derive the mass model of the Milky Way (MW), crucial for Dark Matter (DM) direct and indirect detection, using recent data and a cored dark matter (DM) halo profile, which is favoured by studies of external galaxies.
F. Nesti, P. Salucci
semanticscholar   +1 more source

Understanding the core-halo relation of quantum wave dark matter from 3D simulations. [PDF]

Physical Review Letters, 2014
We examine the nonlinear structure of gravitationally collapsed objects that form in our simulations of wavelike cold dark matter, described by the Schrödinger-Poisson (SP) equation with a particle mass ∼10(-22)  eV. A distinct gravitationally self-bound
Hsi-Yu Schive, M. Liao, Tak-Pong Woo, Shing-Kwong Wong, T. Chiueh, T. Broadhurst, W. Hwang   +6 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source