Oral Nirmatrelvir/Ritonavir Therapy for COVID-19: The Dawn in the Dark? [PDF]
Antibiotics, 2022 Nirmatrelvir/ritonavir (Paxlovid™) is an effective and safe antiviral drug that inhibits the main protease (Mpro), 3CL protease, of SARS-CoV-2. A reduction in COVID-19-related hospitalization or death was observed in patients treated with nirmatrelvir ...
Yuan-Pin Hung +6 more
doaj +2 more sources
Proton‐Driven Transformable 1O2‐Nanotrap for Dark and Hypoxia Tolerant Photodynamic Therapy
Advanced Science, 2022 Despite the clinical potential, photodynamic therapy (PDT) relying on singlet oxygen (1O2) generation is severely limited by tumor hypoxia and endosomal entrapment.
Dapeng Chen +10 more
doaj +2 more sources
Cognitive Behavioural Therapy and Light Dark Therapy for Maternal Postpartum Insomnia Symptoms: Protocol of a Parallel-Group Randomised Controlled Efficacy Trial [PDF]
Frontiers in Global Women's Health, 2021 Background: Symptoms of insomnia are common in new mothers and have been associated with a range of negative maternal and child outcomes. Despite this, interventions to improve maternal postpartum sleep remain scarce.
Sumedha Verma +5 more
doaj +2 more sources
The dark side of the moon: severe therapy-resistant asthma in children
Monaldi Archives for Chest Disease, 2015 Problematic severe asthma is the term used to describe children whose asthma is not responsive to standard therapy with high-dose inhaled corticosteroids and additional controllers. These children need to be assessed by a step-wise systematic protocol in
F.M. De Benedictis, I. Carloni, A. Bush
doaj +3 more sources
Candida krusei Lung Abscess With Black Necrotic Aspirate [PDF]
Respirology Case ReportsA profoundly immunocompromised man developed a large cavitary lung lesion producing black, viscous aspirate, with culture confirming Candida krusei.
Shan Kai Ing, Pon Ying Lau, Nga Hung Ngu
doaj +2 more sources
O005 Cognitive behavioural therapy and light dark therapy for postpartum insomnia symptoms: a randomised controlled trial [PDF]
Sleep Adv, 2021 Verma S +7 more
europepmc +3 more sources
Annals of Medicine, 2023 Introduction Chronotherapeutic interventions for bipolar depression and mania are promising interventions associated with rapid response and benign side effect profiles.
Helle Østergaard Madsen +6 more
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Effects of Laser Therapy on Periodontal Status in Adult Patients Undergoing Orthodontic Treatment
Diagnostics, 2022 Orthodontic treatment with fixed devices should only be indicated in case of a stable, non-active periodontal disease status. Throughout orthodontic treatment, a careful assessment of the periodontal status is advised.
Luminița Lazăr +7 more
doaj +1 more source
Comptes Rendus. Chimie, 2021 Porphyrins bearing imidazolium salts were synthesized and used as N-heterocylic carbene (NHC) precursors for the preparation of gold(I) complexes. The dark toxicity and phototoxicity of the obtained compounds were investigated in vitro on MCF-7 breast ...
Rose, Clémence +5 more
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Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy
Molecules, 2021 To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had good water solubility and low aggregation.
Wei Liu +7 more
doaj +1 more source