Results 101 to 110 of about 308,632 (278)

The use of mobile-assisted virtual reality in fear of darkness therapy

TELKOMNIKA (Telecommunication Computing Electronics and Control), 2019
Fear of darkness is a common psychological problem that may extent to a specific phobia if it is not treated well. Several intervention techniques related to fear and phobia using actual exposure therapy have been studied for decades, however, there were some constraints emerged when the therapist provides a real environment to overcome the patient's ...
Erick Paulus, Mira Suryani, Puspita Adhi Kusuma Wijayanti, Firdaus Perdana Yusuf, Aulia Iskandarsyah   +4 more
openaire   +3 more sources

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

FEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti, Chikahiro Imashiro, Takashi Morikura, Shogo Miyata, Akira Funahashi, Kenjiro Takemura   +5 more
wiley   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Escape from targeted inhibition: The dark side of kinase inhibitor therapy [PDF]

, 2010
Jill Wykosky, Akitake Mukasa, Frank B. Furnari, Webster K. Cavenee   +3 more
openalex   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Polyamine Derived Photosensitizer: A Novel Approach for Photodynamic Therapy of Cancer

Molecules
Polyamines play a pivotal role in cancer cell proliferation. The excessive polyamine requirement of these malignancies is satisfied through heightened biosynthesis and augmented extracellular uptake via the polyamine transport system (PTS) present on the
Hao Deng, Ke Xie, Liling Hu, Xiaowen Liu, Qingyun Li, Donghui Xie, Fengyi Xiang, Wei Liu, Weihong Zheng, Shuzhang Xiao, Jun Zheng, Xiao Tan   +11 more
doaj   +1 more source

The effectiveness and cost effectiveness of dark chocolate consumption as prevention therapy in people at high risk of cardiovascular disease: best case scenario analysis using a Markov model [PDF]

, 2012
Ella Zomer, Alice Owen, Dianna J. Magliano, Danny Liew, Christopher M. Reid   +4 more
openalex   +1 more source

Comparison of real-world treatment outcomes of systemic immunomodulating therapy in atopic dermatitis patients with dark and light skin types [PDF]

, 2022
Angela L. Bosma, Wouter Ouwerkerk, Madeline J. Heidema, David Prieto‐Merino, Michael R. Ardern‐Jones, Paula Beattie, Sara Brown, J.R. Ingram, Alan D. Irvine, Graham S. Ogg, Prakash A. Patel, Nick J. Reynolds, Ross Hearn, Mandy Wan, Richard B. Warren, Richard Woolf, Ariënna Hyseni, Louise A. A. Gerbens, Phyllis I. Spuls, Carsten Flohr, Maritza A. Middelkamp‐Hup   +20 more
openalex   +1 more source

Advantages and limitations of navigation‐based multicriteria optimization (MCO) in selectively sparing pharyngeal constrictor muscles in head and neck radiotherapy treatment planning

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Sparing pharyngeal constrictor muscles (PCMs) during radiotherapy improves patient‐reported swallowing function. This study aimed to explore the feasibility of integrating knowledge‐based planning (KBP) with multicriteria optimization (MCO) in Eclipse v18.0 to selectively spare PCM, quantify the required trade‐off in prophylactic ...
Laura K. Howard, Simon J. P. Meara, Ehab M. Ibrahim, Carl G. Rowbottom   +3 more
wiley   +1 more source