Results 11 to 20 of about 308,632 (278)

Dark-Rearing the rd10 Mouse: Implications for Therapy [PDF]

open access: green, 2011
The moderate rate of retinal degeneration in the rd10(PDE6β rd10 ) mouse makes it a valuable model for therapeutic studies in autosomal recessive retinitis pigmentosa. The peak period of photoreceptor apoptosis occurs between P18 and P25; however, this degeneration can be delayed if the animal is dark-reared from birth. In this study, we find that dark-
Thérèse Cronin   +2 more
openalex   +4 more sources

The dark side of the moon: severe therapy-resistant asthma in children

open access: yesMonaldi Archives for Chest Disease, 2015
Problematic severe asthma is the term used to describe children whose asthma is not responsive to standard therapy with high-dose inhaled corticosteroids and additional controllers. These children need to be assessed by a step-wise systematic protocol in
F.M. De Benedictis, I. Carloni, A. Bush
doaj   +5 more sources

The dark side of the force – constraints and complications of cell therapies for stroke [PDF]

open access: goldFrontiers in Neurology, 2015
Cell therapies are increasingly recognized as a promising option to augment the limited therapeutic arsenal available to fight ischemic stroke. During the last two decades, cumulating preclinical evidence has indicated a substantial efficacy for most cell treatment paradigms and first clinical trials are currently underway to assess safety and ...
Johannes eBoltze   +8 more
openalex   +5 more sources

BLUES - stabilizing mood and sleep with blue blocking eyewear in bipolar disorder – a randomized controlled trial study protocol

open access: yesAnnals of Medicine, 2023
Introduction Chronotherapeutic interventions for bipolar depression and mania are promising interventions associated with rapid response and benign side effect profiles.
Helle Østergaard Madsen   +6 more
doaj   +1 more source

Effects of Laser Therapy on Periodontal Status in Adult Patients Undergoing Orthodontic Treatment

open access: yesDiagnostics, 2022
Orthodontic treatment with fixed devices should only be indicated in case of a stable, non-active periodontal disease status. Throughout orthodontic treatment, a careful assessment of the periodontal status is advised.
Luminița Lazăr   +7 more
doaj   +1 more source

In vitro toxicity and photodynamic properties of porphyrinoids bearing imidazolium salts and N-heterocyclic carbene gold(I) complexes

open access: yesComptes Rendus. Chimie, 2021
Porphyrins bearing imidazolium salts were synthesized and used as N-heterocylic carbene (NHC) precursors for the preparation of gold(I) complexes. The dark toxicity and phototoxicity of the obtained compounds were investigated in vitro on MCF-7 breast ...
Rose, Clémence   +5 more
doaj   +1 more source

Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy

open access: yesMolecules, 2021
To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had good water solubility and low aggregation.
Wei Liu   +7 more
doaj   +1 more source

Gold-Nanorod-Assisted Live Cell Nuclear Imaging Based on Near-Infrared II Dark-Field Microscopy

open access: yesBiology, 2023
Dark-field microscopy offers several advantages, including high image contrast, minimal cell damage, and the absence of photobleaching of nanoprobes, which make it highly advantageous for cell imaging.
Yifeng Shi   +6 more
doaj   +1 more source

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