Results 11 to 20 of about 728,862 (348)

Vasopressor Therapy and the Brain: Dark Side of the Moon [PDF]

open access: yesFrontiers in Medicine, 2020
Sepsis, a leading cause of morbidity and mortality, is caused by a deregulated host response to pathogens, and subsequent life-threatening organ dysfunctions.
Nicholas Heming   +8 more
doaj   +4 more sources

Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies [PDF]

open access: hybridClinical Cancer Research, 2023
Summary The authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells’ HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing ...
Bernard A. Fox   +6 more
openalex   +3 more sources

Resolving the dark side of therapy-driven cancer cell death [PDF]

open access: hybridJournal of Experimental Medicine, 2017
In this issue of JEM, Sulciner et al. (https://doi.org/10.1084/jem.20170681) provide evidence that therapy-induced cancer cell death can, paradoxically, stimulate and accelerate the growth of surviving malignant cells by fueling tumor-promoting inflammation.
Eduardo Bonavita   +2 more
openalex   +4 more sources

Dark-Rearing the rd10 Mouse: Implications for Therapy [PDF]

open access: green, 2011
The moderate rate of retinal degeneration in the rd10(PDE6β rd10 ) mouse makes it a valuable model for therapeutic studies in autosomal recessive retinitis pigmentosa. The peak period of photoreceptor apoptosis occurs between P18 and P25; however, this degeneration can be delayed if the animal is dark-reared from birth. In this study, we find that dark-
Thérèse Cronin   +2 more
openalex   +3 more sources

Data from Photodynamic Therapy: A Light in the Darkness?

open access: gold, 2023
<div>Abstract<p>Photodynamic therapy (PDT) is used to treat localized premalignant or early malignant disease. This study reports the enhanced, systemic antitumor immune response from PDT, suggesting that it may have a potential role as a therapy to address both local and disseminated disease.</p></div>
Alexander Lin, Stephen M. Hahn
openalex   +2 more sources

The dark side of antituberculosis therapy: adverse events involving liver function [PDF]

open access: bronzeEuropean Respiratory Journal, 1995
in 1990. The number of new cases in thesame year was estimated to be as high as 8 million, witha death toll of approximately 3 million [1]. During thenineties, these figures are expected to increase to morethan 10 million new cases and 3.6 million deaths eachyear. Thus, tuberculosis will still remain the leadingcause of death in the world from a single
T. Schaberg
openalex   +4 more sources

Uncovering The Dark Side Of Covid 19 On Nutrition Therapy [PDF]

open access: bronzeClinical Nutrition ESPEN, 2023
Rationale: Critically ill patients have an improved outcome when adequate nutrition therapy guided by indirect calorimetry(IC) is provided. However, several issues like ignorance and technical problems but also workload hamper adequate provision of this cardinal care bundle.
J. Demol   +3 more
openalex   +3 more sources

Home - About - Disclaimer - Privacy