Results 261 to 270 of about 308,632 (278)
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The Dark Side of Targeted Therapy
European Urology, 2011Renal cell carcinoma (RCC) is a relatively rare malignancy from a global perspective. Yearly around the world, approximately 200 000 new cases of RCC are diagnosed and approximately 100 000 patients die of their disease [1]. Management of patients with localized and locally advanced RCC has focused mainly on surgical therapy, as effective adjuvant ...
Christopher G. Wood, Jose A. Karam
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Is there a dark side to thiazide therapy for hypertension?
Nature Reviews Nephrology, 2010Many clinical guidelines recommend thiazide diuretics as first-line treatment for hypertension, even in individuals with mild chronic kidney disease (CKD). However, results from the ACCOMPLISH trial add to growing evidence that thiazide-based therapy does not retard progression of CKD.
Takahiko Nakagawa, Richard J. Johnson
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Clinical and Experimental Optometry, 2013
Extended periods of complete darkness have long been used among other early experiential manipulations to explore the role of visual experience in the development of the visual pathways. In the last decade, short periods of darkness have been used to facilitate the imposition of different or conflicting visual input each day to explore the manner by ...
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Extended periods of complete darkness have long been used among other early experiential manipulations to explore the role of visual experience in the development of the visual pathways. In the last decade, short periods of darkness have been used to facilitate the imposition of different or conflicting visual input each day to explore the manner by ...
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2013
Introduction and Objective The Dark Ages are rightfully characterized by the loss of classic learning, the religious institutionalizing of dogma, the loss of humanism and secular authority, and a Western devolvement of medicine. Patients with stone disease were thus in a double dilemma, there was little in the way of medical therapeutics, and the ...
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Introduction and Objective The Dark Ages are rightfully characterized by the loss of classic learning, the religious institutionalizing of dogma, the loss of humanism and secular authority, and a Western devolvement of medicine. Patients with stone disease were thus in a double dilemma, there was little in the way of medical therapeutics, and the ...
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Out of the Darkness: Group Cognitive Therapy for Depressed Elderly
Journal of Psychosocial Nursing and Mental Health Services, 19911. Depression affects an estimated 50% of the population over age 65. With the current expansion of the elderly in this country, the problem will continue to increase. 2. Depressed individuals view situations negatively when more positive interpretations are equally valid.
J D Zerhusen, W Wilson, K Boyle
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Resisting loneliness' dark pit: a narrative therapy approach
Tizard Learning Disability Review, 2013PurposePeople with learning disabilities want and value friendships and close, intimate, or romantic relationships. However, many people with learning disabilities are socially and emotionally lonely. The purpose of this paper is to describe a novel intervention, using a narrative therapy based group approach, which aimed to ameliorate the negative ...
Adrian Edwards, James Stacey
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Is There a Dark Side to Long-term Proton Pump Inhibitor Therapy?
American Journal of Therapeutics, 2008Proton pump inhibitors (PPIs) are among the most widely used of prescription drugs. They have revolutionized the management of gastroesophageal reflux disease and other acid-related disorders. Although generally safe, concerns about possible adverse effects continue to arise. Some of these, such as gastric neoplasms, are of theoretical concern only and
Colin W. Howden, Thomas B. Nealis
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Cancer development and therapy resistance: spotlights on the dark side of the genome
Pharmacology & Therapeutics, 2018Cancer research has been focusing so far on genetic alterations in protein-coding genes. However, mounting evidence underlines the importance of epigenetic and post-transcriptional events in cancer progression and therapy resistance. Moreover, recent genome-wide studies show that disease-causing mutations and chromosome rearrangements often span areas ...
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Dramatherapy, 1997