Results 51 to 60 of about 728,862 (348)

The saline organic-rich sediments: A short overview. [PDF]

open access: yesAerul şi Apa: Componente ale Mediului, 2018
Organic-rich sediments (or ‘sapropels’) are complex organo-mineral matrices that form at the O2-depleted bottom of stagnant water basins. Besides geochemical transformations, slow rate microbially-driven processes underpin the early diagenesis of these ...
H. L. BANCIU
doaj   +1 more source

A heavy atom free semiconducting polymer with high singlet oxygen quantum yield for photodynamic and photothermal synergistic therapy

open access: yesMaterials & Design, 2021
Semiconducting polymers have been widely used for phototheranostics due to their strong absorbance in near infrared region, high photostability, excellent photothermal conversion ability.
Xujing Zhang   +9 more
doaj   +1 more source

A personal reflection on “depression”: Not only a problem but also a learning opportunity

open access: yesInternational Journal of Narrative Therapy and Community Work, 2023
For most of 2022, I was challenged by depression. One of its effects was to derail action-taking skills in my personal and professional life, leading to a sense of paralysis.
Barry Sullivan
doaj   +1 more source

Disseminated cutaneous squamous cell carcinoma in situ on the face and neck: A case report

open access: yesPifu-xingbing zhenliaoxue zazhi
We report a case of disseminated skin squamous cell carcinoma in situ on the face and neck treated with surgery in combination with photodynamic therapy.
Lihui HE, Wei LIU, Mingyi CHEN
doaj   +1 more source

Maintenance therapy in autoimmune pancreatitis: a weak light into the darkness [PDF]

open access: yesAnnals of Translational Medicine, 2017
Autoimmune pancreatitis (AIP) is a fibro-inflammatory disease of the pancreas with a postulated immune-mediated mechanism (1,2). Two different histologic subtypes have been described, type 1 and type 2 AIP (3). Type 1 AIP is a more aggressive disease in terms of recurrences and extra-pancreatic organ involvement.
Frulloni, Luca   +2 more
openaire   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

The feasibility of conducting non-pharmacological research studies in participants with mania: a grounded theory qualitative analysis of the Ottawa Sunglasses at Night study

open access: yesInternational Journal of Qualitative Studies on Health & Well-Being
Background Feasibility concerns around non-pharmacological interventions can be a barrier against clinical research in individuals with mania. Methods: As part of a randomized controlled trial using blue-blocking vs lightly-tinted glasses, we interviewed
Jessica Yu   +12 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Dual Molecular Design toward a Lysosome-Tagged AIEgen and Heavy-Atom-Free Photosensitizers for Hypoxic Cancer Photodynamic Therapy

open access: yesBiosensors, 2022
To date, a large number of photosensitizers (PS) have introduced heavy atoms to improve the ISC process and 1O2 generation. However, they often show low efficiency in hypoxic conditions, aggregate states, and turn-off PDT in the dark.
Thanh Chung Pham   +8 more
doaj   +1 more source

Micro-computed tomography for the quantification of blocked fibers in hemodialyzers [PDF]

open access: yes, 2018
A novel technique based on micro-CT scanning is developed to quantify coagulation in fibers of hemodialyzers. This objectivation is needed to allow accurate assessment of thrombogenicity of dialyzers used during hemodialysis, for example when comparing ...
Boone, Matthieu   +5 more
core   +2 more sources

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