Results 131 to 140 of about 46,962 (257)

Detection of BCR-ABL kinase domain mutations in CD34+ cells from newly diagnosed chronic phase CML patients and their association with imatinib resistance [PDF]

, 2011
BCR-ABL kinase domain (KD) mutations, the most common cause of imatinib resistance, are infrequently detected in newly diagnosed chronic-phase chronic myeloid leukemia (CP-CML) patients.
Aamer Aleem, Abdul Qayyum, Abid Jamil, Abid Taj, Ahmad Khalid, Ammara Tahir, Ijaz Shah, Mahwish Khan, Mubashar Naqvi, Mudassar Iqbal, Muhammad Abbad, Muhammad Ferhan, Muhammad Khalid, Najeeb ur-Rehman, Riaz ul-Haq, Shahid Baig, Tanveer Akhtar, Tariq Gill, Weng Qin, Zafar Iqbal   +19 more
core   +1 more source

Assessment of Large Granular Lymphocyte during Dasatinib Therapy and its Relation to Deep Molecular Response in Chronic Myeloid Leukemia [PDF]

, 2018
Haiqing Wang, Shupei Ma
openalex   +1 more source

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S. Al‐Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong‐Yi Wang   +22 more
wiley   +1 more source

New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti‐Tumor Activity Against Ewing Sarcoma

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Caroline de Bem Gentz, Thais Helena Maciel Fernandes, Marcela Silva Lopes, Lewis Elson, Andreas Krämer, Lucas Rodrigo de Souza, Isadora Serraglio Fortes, Geórgia Silva Pinto, Martha Cestari Silva Martins, Henrique Barros de Lima, André da Silva Santiago, Lauro José Gregianin, Katlin Brauer Massirer, Mário Henrique Bengtson, Rafael Roesler, Stefan Knapp, Stefan A. Laufer, Saulo Fernandes de Andrade   +17 more
wiley   +1 more source

Prospects for non-immunological molecular therapeutics in melanoma [PDF]

, 2010
In 2006 there were 60,000 new cases of cutaneous melanoma in the European Union and 13,000 deaths (www.europeancancerleagues.org). Currently available systemic treatment options for metastatic melanoma, including both cytotoxic and immunologic therapies,
Crown, John, Eustace, Alexander J., Mahgoub, Thamir, O'Donovan, Norma, Tryfonopoulos, Dimitrios   +4 more
core  

Editorial Commentary: Dasatinib With Quercetin Shows Promise in Decreasing Age-Related Senescence in the Rotator Cuff Tendon—Can It Work Elsewhere? [PDF]

, 2023
F. Alan Barber
openalex   +1 more source

Predictors of Response to Imatinib Therapy and Long‐Term Outcomes in Paediatric and Adolescent Patients With Chronic Myeloid Leukaemia

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background Chronic myeloid leukaemia (CML) is an infrequent myeloproliferative neoplasm in the paediatric population as compared to adults. Despite vast progress in understanding the disease biology and therapy of CML‐chronic phase (CML CP), the applicability of risk scoring systems in practice and prognostic factors in children remain grey ...
Souvik Saha, Sanjeev Yadav, Manish Kumar Singh, Khaliqur Rahman, Dinesh Chandra, Ruchi Gupta, Rajesh Kashyap   +6 more
wiley   +1 more source

Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. [PDF]

, 2019
PURPOSE:The purpose of this study was to determine the impact of food on gastric pH and the ability of over the counter betaine hydrochloride (BHCl) acid to reacidify gastric pH after food-induced elevations in gastric pH.
Benet, Leslie Z, Frassetto, Lynda A, Surofchy, Dalga D   +2 more
core  

Multi‐omics analysis identifies PUS7 as an immune modulator driving NETs‐mediated macrophage polarization in pancreatic cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
PUS7 reshapes the PDAC immune landscape primarily by inducing NETs, which drive macrophage polarization from M1 to M2, fostering immune suppression and tumour progression. The inhibitory effects of S428‐1145 and DNase I on pancreatic cancer are mediated through blocking the PUS7/NETs/M2 macrophage pathway.
Jike Fang, Shiye Ruan, Yajie Wang, Yue Chen, Fuxin Huang, Zhongyan Zhang, Chuanzhao Zhang, Baohua Hou, Shanzhou Huang   +8 more
wiley   +1 more source

Trastuzumab-Targeted Biodegradable Nanoparticles for Enhanced Delivery of Dasatinib in HER2+ Metastasic Breast Cancer [PDF]

, 2019
Enrique Niza, María del Mar Noblejas‐López, Iván Bravo, Cristina Nieto‐Jiménez, José A. Castro‐Osma, Jesús Canales‐Vázquez, Agustín Lara‐Sánchez, Eva María Galán‐Moya, Miguel Burgos, Alberto Ocaña, Carlos Alonso‐Moreno   +10 more
openalex   +1 more source