Results 131 to 140 of about 54,207 (313)

Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts

Molecular Cancer, 2010
Cancer associated fibroblasts (CAFs) play a critical role for growth, invasion, and metastasis of cancer. Therefore, targeting CAFs with small molecule inhibitors may be an attractive anti-tumor strategy. The current study aims to identify small molecule
van der Kuip Heiko, Friedel Godehard, Sonnenberg Maike, Mürdter Thomas E, Schmid Jens O, Haubeiss Silke, Aulitzky Walter E   +6 more
doaj   +1 more source

Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801.

Blood Advances, 2020
Acute myeloid leukemia (AML) with either t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22) is referred to as core binding factor (CBF) AML. Although categorized as favorable risk, long-term survival for these patients is only ∼50% to 60%.
G. Marcucci, Susan Geyer, K. Laumann, Weiqiang Zhao, D. Bucci, G. Uy, W. Blum, Ann-Kathrin Eisfeld, T. Pardee, E. Wang, W. Stock, J. Kolitz, J. Kohlschmidt, K. Mrózek, C. Bloomfield, R. Stone, R. Larson   +16 more
semanticscholar   +1 more source

BCR-ABL residues interacting with ponatinib are critical to preserve the tumorigenic potential of the oncoprotein [PDF]

, 2013
Patients with chronic myeloid leukemia in whom tyrosine kinase inhibitors (TKIs) fail often present mutations in the BCR-ABL catalytic domain. We noticed a lack of substitutions involving 4 amino acids (E286, M318, I360, and D381) that form hydrogen ...
Alessandro Pandini, Chiara Romano, Deininger M., Elena Tirrò, Franca Fraternali, Francesco Di Raimondo, Livia Manzella, Michele Massimino, Nagar B., Paolo G. Vigneri, Pietro Buffa, Shah N. P.   +11 more
core   +1 more source

Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging

Aging Cell, EarlyView.
Age‐related increases in IGF‐1 expression in the skin accelerate stem cell exhaustion and senescence by impairing SIRT1 function, ultimately driving hair follicle aging. Conversely, activating SIRT1, clearing senescent cells, or adopting dietary restriction can mitigate excessive IGF‐1 signaling and provide a promising strategy to rejuvenate hair ...
Yang Wang, Jian Yang, Yue Luo, Zhiqiang Zhao, Yawen Yuan, Juan Li, Yang Liu, Yong Yi, Xiaoke Xu, Yuankunyu Lan, Juan Zou, Qintong Li, Liang Wang, Yang Pan, Yuanhan Yang, Muzhao Xiong, Min Wu, Jinsong Li, Weiyuxin Li, Yujun Zhang, Yang Cao, Yi Zhu, Zhi‐Xiong Jim Xiao   +22 more
wiley   +1 more source

Pharmacokinetics of dasatinib for Philadelphia-positive acute lymphocytic leukemia with acquired T315I mutation

Journal of Hematology & Oncology, 2012
Background The BCR-ABL T315I kinase domain mutation is insensitive to dasatinib therapy for Philadelphia-positive acute lymphoid leukemia (Ph + ALL) patients.
Takahashi Naoto, Miura Masatomo, Scott Stuart A, Niioka Takenori, Sawada Kenichi   +4 more
doaj   +1 more source

STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]

, 2018
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F, Carissimi, S, Chichiarelli, S, Eufemi, M, Giamogante, F, Macone, A, Paglia, G, Rubini, E   +7 more
core   +2 more sources

Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles

Aging Cell, EarlyView.
A senomorphic miRNA cocktail (E5), consisting of miR‐181a‐5p, miR‐92a‐3p, miR‐21‐5p, and miR‐186‐5p, was identified from a pool of miRNAs enriched in extracellular vesicles (EVs) derived from multiple functional human stem cell types. E5 reduces senescence and SASP markers both in cell culture and in aged mice.
Tianpeng Zhang, Allancer D. C. Nunes, Jieun Lee, Dana Larocca, Giovanni Camussi, Sai Kiang Lim, Vicky U. Bascones, Luise Angelini, Ryan D. O'Kelly, Xiao Dong, Laura J. Niedernhofer, Paul D. Robbins   +11 more
wiley   +1 more source

Dasatinib Inhibits Lung Cancer Cell Growth and Patient Derived Tumor Growth in Mice by Targeting LIMK1

Frontiers in Cell and Developmental Biology, 2020
Lung cancer is a leading cause cancer-related death with diversity. A promising approach to meet the need for improved cancer treatment is drug repurposing.
Man Zhang, Jie Tian, Rui Wang, Mengqiu Song, Mengqiu Song, Ran Zhao, Ran Zhao, Hanyong Chen, Kangdong Liu, Kangdong Liu, Jung-Hyun Shim, Jung-Hyun Shim, Feng Zhu, Zigang Dong, Zigang Dong, Mee-Hyun Lee, Mee-Hyun Lee, Mee-Hyun Lee   +17 more
doaj   +1 more source

Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma.

Journal of Clinical Investigation, 2020
BACKGROUND Pediatric and adult high-grade glioma (HGG) frequently harbor PDGFRA alterations. We hypothesized that co-treatment with everolimus may improve the efficacy of dasatinib in PDGFRα-driven glioma through combinatorial synergism and increased ...
Z. Miklja, Viveka N Yadav, R. Cartaxo, Ruby G. Siada, Chase C. Thomas, Jessica R. Cummings, B. Mullan, Stefanie Stallard, A. Paul, Amy K. Bruzek, Kyle Wierzbicki, T. Yang, T. Garcia, Ian Wolfe, M. Leonard, P. Robertson, H. Garton, D. Wahl, H. Parmar, J. Sarkaria, C. Kline, S. Mueller, T. Nicolaides, Chana L Glasser, S. Leary, S. Venneti, Chandan Kumar-Sinha, A. Chinnaiyan, R. Mody, M. Pai, T. Phoenix, B. Marini, C. Koschmann   +32 more
semanticscholar   +1 more source

Dasatinib in chronic myeloid leukemia: a review

Therapeutics and Clinical Risk Management, 2009
Deregulated BCR-ABL tyrosine kinase (TK) activity is the molecular marker for chronic myeloid leukemia (CML), which provides an identifiable target for developing therapeutic agents. Imatinib mesylate, a BCR-ABL TK inhibitor, is the frontline therapy for CML.
Dolly G Aguilera, Apostolia Maria Tsimberidou   +1 more
openaire   +5 more sources