Results 141 to 150 of about 46,962 (257)
Inhibition of IKKβ/NF-κB signaling pathway to improve Dasatinib efficacy in suppression of cisplatin-resistant head and neck squamous cell carcinoma [PDF]
, 2020 Zejia Yang +3 more
openalex +1 more source
Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions
MedComm, Volume 7, Issue 1, January 2026.The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin +3 more
wiley +1 more source
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management
Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh +4 more
wiley +1 more source
Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension? [PDF]
, 2011 Jan K. Hennigs +7 more
openalex +1 more source
A Proteomics Resource Investigating Fibrosis: Proof‐of‐Concept for Identifying Novel Drug Candidates
PROTEOMICS, Volume 26, Issue 1, Page 94-99, January 2026.ABSTRACT Fibrosis is characterised by inappropriate wound healing and the buildup of excessive fibrous connective tissue, in particular within the extracellular matrix (ECM). This can occur in multiple organs, ultimately leading to organ failure. Despite the high burden of fibrosis, treatment options only delay disease progression.
Hanne Devos +9 more
wiley +1 more source
Exosome‐Based Cartilage‐Targeted Delivery System: Strategies and Applications
Small Science, Volume 6, Issue 1, January 2026.Construction strategies and applications of cartilage‐targeting exosomes. With the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health. Therefore, targeted therapy for cartilage is becoming more
Yao Wang +3 more
wiley +1 more source
Aging Cell, Volume 25, Issue 1, January 2026.hAMSC‐sEVs rejuvenate β cells and improve glycaemic control via the miR‐21‐5p/IL‐6RA/STAT3/MCU axis, restoring mitochondrial Ca2+ homeostasis and insulin secretion in aged T2DM mice. ABSTRACT Targeting senescent pancreatic β‐cells represents a promising therapeutic avenue for age‐related diabetes; however, current anti‐senescence strategies often ...
Lei Xiao +8 more
wiley +1 more source
A strange cause of chylothorax- Dasatinib induced
Journal of Association of Pulmonologist of Tamil Nadu, 2018 Dasatinib is a potent second-generation tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia. Pulmonary side effects like pleural effusion due fluid retention are common.
M Natraj +5 more
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Терапевтический архив, 2009 Aim. To analyse resistance to imatinib therapy, efficacy and safety of dasatinib. Material and methods. A total of 18 patients with chronic myeloid leukemia (CML) in a chronic stage received dasatinib for 9-30 months (median 30 months) to September 2008.
Ol'ga Yur'evna Vinogradova +25 more
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