Results 161 to 170 of about 54,207 (313)

In vivo kinetics of kinase domain mutations in CML patients treated with dasatinib after failing imatinib [PDF]

, 2007
Jamshid S. Khorashad, Dragana Milojković, Puja Mehta, Mona Anand, Sara Ghorashian, Alistair Reid, Valeria De Melo, Anna Babb, Hugues de Lavallade, Eduardo Olavarría, David Marín, John M. Goldman, Jane F. Apperley, Jaspal Kaeda   +13 more
openalex   +1 more source

Dasatinib overcomes AML cells resistant to BCL2 inhibition by degrading MCL1

British Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) is a severe disease occurring mainly in the elderly population. Venetoclax (VEN) combined with azacitidine has changed the paradigm of treatment of AML. Nevertheless, approximately 30% of patients are primary refractory to VEN (VEN‐R), with no current therapeutic option.
Sylvain Garciaz, Camille Montersino, Maxence Bourgoin, Arnaud Jacquel, Rémy Castellano, Arnaud Guille, Max Chaffanet, François Bertucci, Marie‐Anne Hospital, José Adélaïde, Patrick Auberger, Norbert Vey, Yves Collette   +12 more
wiley   +1 more source

Prospects for non-immunological molecular therapeutics in melanoma [PDF]

, 2010
In 2006 there were 60,000 new cases of cutaneous melanoma in the European Union and 13,000 deaths (www.europeancancerleagues.org). Currently available systemic treatment options for metastatic melanoma, including both cytotoxic and immunologic therapies,
Crown, John, Eustace, Alexander J., Mahgoub, Thamir, O'Donovan, Norma, Tryfonopoulos, Dimitrios   +4 more
core  

Bosutinib mitigates inflammation in experimental sepsis

European Journal of Clinical Investigation, EarlyView.
Abstract Background Sepsis, a leading cause of death globally, lacks targeted and effective treatment. Its pathophysiology involves unbalanced inflammation, marked by a high release of inflammatory mediators, leukocyte recruitment, vascular changes and dysfunction of the nervous and respiratory systems. Src family tyrosine kinases (SFK) play a critical
C. M. C. Cunha, V. H. P. Abreu, V. Estato, G. M. V. Soares, B. P. T. Moraes, G. P. Oliveira, J. D. Silva, P. L. Silva, R. Immler, P. R. Rocco, M. Sperandio, A. R. Silva, P. T. Bozza, H. C. Castro‐Faria‐Neto, C. F. Gonçalves‐de‐Albuquerque   +14 more
wiley   +1 more source

Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells [PDF]

, 2007
Sangkil Nam, Ann H. Williams, Adina Vultur, Alan F. List, Kapil N. Bhalla, David Smith, Francis Y. Lee, Richard Jove   +7 more
openalex   +1 more source

Treatment‐Free Remission in Chronic Myeloid Leukemia: Revisiting the “W” Questions

European Journal of Haematology, EarlyView.
ABSTRACT Chronic myeloid leukemia (CML) has undergone a transformation from a fatal disease to a chronic, manageable condition with the advent of tyrosine kinase inhibitors (TKIs), particularly imatinib. This shift has significantly improved survival rates, and for some patients, achieving deep molecular response (DMR) has made treatment‐free remission
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Nicola Amodio, Caterina Labanca, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Fortunato Morabito, Massimo Gentile   +9 more
wiley   +1 more source

Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/“triple-negative” breast cancer cell lines growing in vitro [PDF]

, 2007
Richard S. Finn, Judy Dering, Charles Ginther, Cindy Wilson, Padraic Glaspy, Nishan Tchekmedyian, Dennis J. Slamon   +6 more
openalex   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation [PDF]

, 2007
Andrew E. Schade, Gary L. Schieven, Robert Townsend, Anna Jankowska, Vojkan Susulic, Rosemary Zhang, Hadrian Szpurka, Jaroslaw P. Maciejewski   +7 more
openalex   +1 more source

Molecular Classification Based on the Gene Expression Profiles in Canine Histiocytic Sarcoma Cells

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT The molecular abnormalities of canine histiocytic sarcoma (CHS) remain to be elucidated. We previously revealed that the sensitivities to dasatinib and trametinib were significantly various among CHS cell lines, indicating the differences in underlying molecular abnormalities. In the present study, we performed RNA sequencing analysis using 11
Hiroki Sakuma, Hirotaka Tomiyasu, Akiyoshi Tani, Yuko Goto‐Koshino, Makoto Bonkobara, Masaru Okuda   +5 more
wiley   +1 more source