Results 31 to 40 of about 100,904 (263)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Smash and DASH with Cas9 [PDF]
Genome Biology, 2016 DeRisi and colleagues present a creative application for Cas9 in vitro, using it to deplete unwanted sequence from DNA libraries. It seems plausible that the in vitro use of CRISPR/Cas9 has unrealized potential to revolutionize the practice of molecular biology well beyond genome editing.
Ramani, Vijay, Shendure, Jay
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Effect of shock wave therapy combined with resisted exercise on shoulder pain
Фізична реабілітація та рекреаційно-оздоровчі технологіїPurpose. Shoulder dysfunction is a common musculoskeletal complaint that impacts pain, function, and mobility. While Shock Wave Therapy (SWT) and resisted exercises are both established interventions, their combined effect has not been widely studied ...
Madhavendra Kumar Singh +3 more
doaj +1 more source
Helsinki Design Lab Ten Years Later
She Ji: The Journal of Design, Economics and Innovation, 2020 Four principals. Five years. Two books, five pamphlets, and a series of posters. A website of 130,000 words. A handful of online videos. More than one hundred lectures on five continents. Eight public-facing projects. A dozen studio workshops.
Bryan Boyer
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Cherta (Dash) and Chertochka (Hyphen) in the History of Russian Writing
СибСкриптThe article traces the terms cherta (dash) and chertochka (small dash; hyphen) and their semantics in the system of the Russian linguistic terminology. As the Russian graphics of the 9th–18th centuries remain understudied, so does the lexical status of ...
Andrey V. Ivanov
doaj +1 more source
Гуманитарные и юридические исследования, 2021 Punctuation systems of any language, as well as the language itself, are in constant development. In the twentieth-twenty first centuries new punctuation trends appear, some of them become dominant when placing punctuation marks with different syntactic ...
Irina Ubushaeva
doaj
Towards a Scottish Safe Haven Federation.
International Journal of Population Data Science, 2022 Objectives Building upon the Scottish Safe Haven Network’s (SSHN) collaborative experience to develop an exemplar dataset on Scottish national level laboratory tests within the SSHN.
Chuang Gao +5 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source