Results 91 to 100 of about 1,173,915 (264)

A Behavioral Approach for LPV Data-Driven Representations

IEEE Transactions on Automatic Control
In this paper, we present a data-driven representation for linear parameter-varying (LPV) systems, which can be used for direct data-driven analysis and control of such systems. Specifically, we use the behavioral approach to develop a data-driven representation of the finite-horizon behavior of LPV systems for which there exists a kernel ...
Chris Verhoek, Ivan Markovsky, Sofie Haesaert, Roland Tóth   +3 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A data driven approach to urban area delineation using multi source geospatial data

Scientific Reports
This study introduces a data-driven, bottom-up approach to urban delineation, integrating feature engineering with the Density-Based Spatial Clustering of Applications with Noise (DBSCAN) algorithm, which represents a significant improvement in precision
Chenyu Fang, Lin Zhou, Xinyue Gu, Xing Liu, Martin Werner   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A data‐driven genome annotation approach for cassava

The Plant Journal
SUMMARY Genome annotation files play a critical role in dictating the quality of downstream analyses by providing essential predictions for gene positions and structures. These files are pivotal in decoding the complex information encoded within DNA sequences.
Swetha Chenna, Maxim Ivanov, Tue Kjærgaard Nielsen, Karina Chalenko, Evy Olsen, Kirsten Jørgensen, Albin Sandelin, Sebastian Marquardt   +7 more
openaire   +4 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A Data-Driven Approach to Discovering Process Choreography

Algorithms
Implementing approaches based on process mining in inter-organizational collaboration environments presents challenges related to the granularity of event logs, the privacy and autonomy of business processes, and the alignment of event data generated in ...
Jaciel David Hernandez-Resendiz, Edgar Tello-Leal, Marcos Sepúlveda   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source