Results 181 to 190 of about 33,241,813 (298)

A Data-Driven Approach for Comparing Gaze Allocation Across Conditions. [PDF]

J Eye Mov Res
Prosser J, Metzger A, Toscani M.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Eigen-guided transformer: A data-driven approach for chronic kidney disease forecasting. [PDF]

PLoS One
Saeed F, Aldera S.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A data-driven approach to identifying and evaluating connectivity-based neural correlates of conscious visual perception. [PDF]

Neurosci Conscious
Bryant AG, Whyte CJ.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

A Model-driven Approach to Data Structure Conceptualization [PDF]

Annals of computer science and information systems, 2015
Sonja Ristić, Slavica Kordić, Milan Čeliković, Vladimir Dimitrieski, Ivan Luković   +4 more
doaj   +1 more source

An Expert-Derived Data-Driven Approach to Identifying Medicaid Children at Risk of Out-of-Home Placement: Development, Application, and Data-Sharing Considerations. [PDF]

Med Care
Hardy RY, Ciccone DP, Bailey E, Bozada S, Donnelly E, Tossone K, Chisolm DJ.   +6 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A data driven approach to address missing data in the 1970 British birth cohort. [PDF]

BMC Med Res Methodol
Katsoulis M, Narayanan MK, Dodgeon B, Ploubidis GB, Silverwood RJ.   +4 more
europepmc   +1 more source