Results 211 to 220 of about 1,173,915 (264)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Predicting Stroke Risk Using Machine Learning: A Data-Driven Approach to Early Detection and Prevention. [PDF]

Stroke Res Treat
Sutcu M, Jouda D, Yildiz B, Katrib J, Almustafa KM.   +4 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Identification of preschool children's physical fitness phenotypes and their association with multidimensional body shape indicators: a data-driven approach with risk prediction modeling. [PDF]

Front Public Health
Chen X, Zhao D, Zhang A, Pan X, Wang C, Chen J, Zhang Y.   +6 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Data-driven approach to elucidate the correlation between photocatalytic activity and rate constants from excited states. [PDF]

Chem Sci
Kunisada R, Hayashi M, Rohlfs T, Nagano T, Sano K, Inai N, Noto N, Ogaki T, Matsui Y, Ikeda H, García Mancheño O, Yanai T, Saito S.   +12 more
europepmc   +1 more source

Fine-Tuning Photochemical Immunogenic Cell Death by a Panel of Verteporfin-Lipid Nanoparticles: A Data-Driven Approach. [PDF]

Small Sci
Shah N, Quaye MB, Soma SR, Vadlamudi MS, Mahmoud D, Malkoochi A, Aileni TR, Bhandari C, Karambelkar K, Hasan T, Korbelik M, Fei B, Song X, Obaid G.   +13 more
europepmc   +1 more source

Data-driven Approaches in Paleontology

, 2022
openaire   +1 more source

A data-driven approach to optimizing waiting times in outpatient pharmacy services: Interrupted time series analysis. [PDF]

Explor Res Clin Soc Pharm
Alghamdi H, Alshihayb TS, Alharbi Y, Alawagi M, Aleissa A, Albogami Y.   +5 more
europepmc   +1 more source