Results 201 to 210 of about 5,532,221 (266)

Cumulative Frameworks as a Pragmatic Alternative to Multivariable Modeling in Rare-Event Clinical Settings: A Coronary Care Unit Case Study. [PDF]

Methods Protoc
Vîrtosu DM, Crișan S, Pătru O, Dragomir A, Luca S, Băghină RM, Lazăr MA, Cozlac AR, Iurciuc S, Luca CT.   +9 more
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Assessing National Health Research System in a resource-limited setting: Insights from Indonesia. [PDF]

PLoS One
Dharmawan T, Sutoyo DA, Qorina F, Gamalliel N, Kurniawan M, Kusuma D, Fuady A.   +6 more
europepmc   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

The Global Gap in the Hemophilia Paradigm Shift: Disparities in Research, Care, and Musculoskeletal Health. [PDF]

Hematol Rep
Querol-Giner F, Querol-Giner M, Chimeno-Hernández A, Alberola-Zorrilla P, Pérez-Alenda S, Bonanad S, Querol-Fuentes F.   +6 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Governance of antimicrobial resistance in Central Africa (2015-2025): a systematic review of policies, One Health coordination and funding. [PDF]

JAC Antimicrob Resist
Kamsu GT, Djuikoue IC, Thumamo Pokam BD, Seugnou Nana CD, Ngandjui Yonga C, Mboupaing MG, Marehin MS, Makaya Danguil Nieko NP, Sanou Kue F, Banze Mewehu T, Tseuko D, Hironi S, Mboliyou MT, Gatse Bouya RA, Apalata TR, Antoine-Moussiaux N.   +15 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Prediction of 30-Day All-Cause Hospital Readmissions Using Limited Structured Electronic Health Record Data: Retrospective Comparative Study. [PDF]

JMIR Form Res
Ghosh R, Khezrimotlagh D, Imanpour S, Shvartsman I.   +3 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source