Extrapolation of Animal Carcinogenicity Data: Limitations and Pitfalls [PDF]
Laboratory-generated animal bioassay data often serve as the basis for estimating potential human cancer risk. However, there is no single procedure that has been universally accepted as the method of choice for extrapolating experimentally observed results to the low exposure levels that are generally of public health concern.
openaire +2 more sources
Objectives To quantify and describe the use of real-world data (RWD) in National Institute for Health and Care Excellence (NICE) oncology technology appraisal (TA) final appraisal determination documents.Design A systematic literature review was ...
Lewis Carpenter +3 more
doaj +1 more source
Towards examining and addressing the danger of unaccompanied migrant minors going missing
The phenomenon of missing children is complex, further complicated by the specific circumstances of missing unaccompanied migrant minors. Owing to the (often forced) migration, these children have moved through different countries with diverse ...
Isabelle Brantl +5 more
doaj +1 more source
The Data‐Limited Methods Toolkit (
Abstract A simulation‐based approach known as management strategy evaluation (MSE) is increasingly used by resource managers to identify management procedures that are robust to uncertainties in system dynamics. The majority of global fish populations are data limited and there is large uncertainty over their population and exploitation dynamics ...
Thomas R. Carruthers, Adrian R. Hordyk
openaire +1 more source
Density-Functional Theory of Quantum Freezing: Sensitivity to Liquid-State Structure and Statistics
Density-functional theory is applied to compute the ground-state energies of quantum hard-sphere solids. The modified weighted-density approximation is used to map both the Bose and the Fermi solid onto a corresponding uniform Bose liquid, assuming ...
A R Denton +28 more
core +1 more source
Public spending for illegal drug and alcohol treatment in hospitals: an EU cross-country comparison [PDF]
Background: In view of the current economic crisis and the resulting austerity measures being implemented by governments across Europe, public expenditure for substance abuse treatment has increasingly become a subject of discussion.
Christiaens, Johan +2 more
core +3 more sources
Stability Analysis of Support Anchor Bolt in the Process of Surrounding Rock Fracture Evolution
Various diseases and failures inevitably appear on expressway roadways in water-rich strata under the long-term erosion of water. It is very difficult to support the surrounding rock of a water-rich roadway because water will corrode the anchorage bond ...
Juncai Cao +5 more
doaj +1 more source
The brown-marbled grouper (Epinephelus fuscoguttatus), a high-value species in international trade, has experienced population declines due to intensive fishing.
Yudi Herdiana +5 more
doaj +1 more source
Metadynamics for Training Neural Network Model Chemistries: a Competitive Assessment
Neural network (NN) model chemistries (MCs) promise to facilitate the accurate exploration of chemical space and simulation of large reactive systems. One important path to improving these models is to add layers of physical detail, especially long-range
Herr, John E. +4 more
core +1 more source
Weekly versus three weeks chemotherapy for advanced ovarian cancer. A meta-analysis [PDF]
Aim: Three weeks paclitaxel and carboplatin has been considered the standard of care for primary treatment of ovarian cancer (OC). Whether weekly therapy will further improve the clinical outcomes or not is still unclear.
De Felice, Francesca +8 more
core +1 more source

