Results 241 to 250 of about 37,394,520 (286)

Stakeholder Perspectives and Perceived Usability of an AI-Enabled Stroke Rehabilitation Platform: A Multicentre Mixed-Methods Focus Group Study With Stroke Survivors, Caregivers, and Clinicians. [PDF]

Health Expect
Abi Saab P, Mandigout S, Danesin L, Burgio F, Serena M, Chivite I, Fiorillo R, López J, Szymanski C, Chira D, Truță A, Strilciuc Ș, Vielotte S, Daviet JC, Mura A, Verschure P.   +15 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Relationship-Building and Care Practices of Home-Visiting Nurses Caring for Children With Medical Complexity and Their Families in Japan: A Qualitative Study. [PDF]

Jpn J Nurs Sci
Fukui S, Matsuoka M.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Safety of Multiple Sclerosis Treatments During Pregnancy: An Overview of the EU Regulatory Approach to Risk Management Planning. [PDF]

Pharmacoepidemiol Drug Saf
Strassmann V, Gault N, Stark AK, Vaillant T, Berbain T, Martirosyan L, Sarinic VM, Nordeng HME.   +7 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Linac performance benchmarking: Feasibility of a web-based tool for comparison of local machine performance check (MPC) results with the global community. [PDF]

J Appl Clin Med Phys
May L, Barnes MP, Pearson M, Zwan B, Baeza-Ortega JA, Cooper B, Hussein M, Mishra A, Tan SJE, Zifodya J, Greer PB, Clark CH, Lehmann J.   +12 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Remote Sensing for Operational Surveillance of Mosquito-Borne Diseases. [PDF]

Geohealth
Ash LV, Willard LL, Harrod KK, Tucker CJ, Linthicum KJ, Anyamba A, Gibson S, Han BA, Kramer AM.   +8 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source