Results 291 to 300 of about 66,190,054 (394)

Priorities for New Data Collection. [PDF]

Dev Sci
MacWhinney B, Snow C.
europepmc   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Ethical sourcing in the context of health data supply chain management: a value sensitive design approach. [PDF]

JAMIA Open
Nebeker C, Bélisle-Pipon JC, Collins BX, Cordes A, Ferryman K, McInnis BJ, McWeeney SK, Novak LL, Rose S, Yracheta JM, Williams IC, Jiang X, Clayton EW, Malin BA, Bridge2AI Ethical, Legal And Social Implications AI Working Group .   +15 more
europepmc   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Experiences of Health Research Data Sharing Among Researchers in Sub-Saharan Africa: Cross-Sectional Study. [PDF]

JMIR Form Res
Sukums F, Ngowi B, Chaula R, Weiszhar KL, Kalinga A, Ivanova O, Prazeres da Costa C, Hoerauf A, Sahay S, Noormahomed EV, Debrah LB, Sikasunge C, Ngowi H, Winkler AS.   +13 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Does Adjuvant Metformin Reduce Olanzapine-Induced Metabolic Adverse Effects in Patients Diagnosed With Schizophrenia. [PDF]

Neuropsychopharmacol Rep
Butt A, Sadiq S.
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Opportunities and Challenges of Using Big Data to Detect Drug-Drug Interaction Risk [PDF]

, 2019
Chasioti D., Institute of Medicine Committee on Data Standards for Patient Safety   +1 more
core   +1 more source

A public mid-density genotyping platform for cultivated cranberry (Vaccinium macrocarpon Aiton). [PDF]

Plant Genome
Chen S, Lin M, Taniguti CH, Tang X, de la Torre F, Sideli GM, Iorizzo M, Edger PP, Neyhart J, Zalapa J, Bassil N, Heller-Uszynska K, Zhao D, Beil CT, Sheehan MJ.   +14 more
europepmc   +1 more source