Results 331 to 340 of about 63,638,251 (398)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Automated multi-instance REDCap data synchronization for NIH clinical trial networks. [PDF]

JAMIA Open
Adams MCB, Hudson C, Chen W, Hurley RW, Topaloglu U.   +4 more
europepmc   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Bridging the gap between R and Python in bulk transcriptomic data analysis with InMoose. [PDF]

Sci Rep
Colange M, Appé G, Meunier L, Weill S, Johnson WE, Nordor A, Behdenna A.   +6 more
europepmc   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Methods for computing and intercomparing radiation data

, 1919
W. W. Coblentz
openalex   +1 more source

Evaluating the effectiveness of data governance frameworks in ensuring security and privacy of healthcare data: A quantitative analysis of ISO standards, GDPR, and HIPAA in blockchain technology. [PDF]

PLoS One
Ahmed A, Shahzad A, Naseem A, Ali S, Ahmad I.   +4 more
europepmc   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Handbook of the flora of Philadelphia and vicinity, containing data relating to the plants within the following radius: eastern Pennsylvania; all of New Jersey except the northern counties; and New Castle County, Delaware, with keys for identification of species

, 1905
Ida A. Keller, Stewardson Brown
openalex   +2 more sources

Retrospective Assessment of Endometriosis Pain Over the Life Course: A Reliability Study Within the ComPaRe-Endometriosis Cohort. [PDF]

Eur J Pain
Gouesbet S, Lambert S, Amazouz H, Breton Z, Tran VT, Missmer S, Kvaskoff M.   +6 more
europepmc   +1 more source