Results 71 to 80 of about 14,717,329 (312)

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

Sub-suppliers model 4.0 and knowledge discovery in industry supply chain

open access: yesSmart Cities and Regional Development Journal
Web 4.0 revolution and the abundance of industrial data in the current business environment allow each industrial company to innovate in a diversity of ways.
Milena KRUMOVA, Evgeniy PETROV
doaj   +1 more source

Report da Intergeo 2018

open access: yesGEOmedia, 2018
INTERGEO 2018 is the international Geo-ICT showcase for data acquisition systems. Topographic tools always more performing, and interest in the laser scanner.
Giacomo Uguccioni
doaj   +1 more source

Data, DIKW, Big Data and Data Science

open access: yesProcedia Computer Science, 2014
AbstractIn this paper we discuss the relationship between data and DIKW, that the data only evolves to knowledge, which may have some value, but if without the wisdom we still could let the knowledge be really useful to people. Now the big data occupies much attention in some extent for his volume, velocity, and variety.
Zhang Lingling, Gu Jifa
openaire   +2 more sources

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

open access: yesFEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

The BrainHealth Databank: a systems approach to data-driven mental health care and research

open access: yesFrontiers in Neuroinformatics
IntroductionMental health care is undermined by fragmented data collection, as incomplete datasets can compromise treatment efficacy and research. The BrainHealth Databank (BHDB) at the Centre for Addiction and Mental Health (CAMH) establishes the ...
Jose Arturo Santisteban   +33 more
doaj   +1 more source

Open Access Data in Polar and Cryospheric Remote Sensing

open access: yesRemote Sensing, 2014
This paper aims to introduce the main types and sources of remotely sensed data that are freely available and have cryospheric applications. We describe aerial and satellite photography, satellite-borne visible, near-infrared and thermal infrared sensors,
Allen Pope   +3 more
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

open access: yesFEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki   +4 more
wiley   +1 more source

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