Results 101 to 110 of about 12,309,063 (288)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
IEEE Photonics Journal, 2018 All-fiber orbital angular momentum (OAM) amplifier with high purity and broadband spectrum gain based on a fused taper vortex-beam coupler (VBC) has been studied.
Jianxiang Wen +7 more
doaj +1 more source
The combined approach to ontology-based data access [PDF]
, 2011 The use of ontologies for accessing data is one of the most exciting new applications of description logics in databases and other information systems.
Kontchakov, Roman +4 more
core +5 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Heterogeneous Relational Databases for a Grid-enabled Analysis Environment [PDF]
, 2005 Grid based systems require a database access mechanism that can provide seamless homogeneous access to the requested data through a virtual data access system, i.e.
Ali, Arshad +12 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Multi-access fiber optic data bus using FDM/FSK [PDF]
The major thrust was to develop a T coupler with very low (0.1 0.2dB) in-line loss. This is essential to any multiaccess bus structure where the word multi implies fifteen or more nodes on the bus, and it is tacitly assumed to be a passive bus ...
Zanger, H.
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Free Access to Primary Data Should Be a Right [PDF]
Few things are as important for development as the availability of data and unfettered access. Without data there can be no needs assessment. It will scarcely be possible to design effective policies or to implement, monitor and evaluate them.
Rafael Guerreiro Osorio
core