Results 201 to 210 of about 9,437,828 (334)

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Data analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program. [PDF]

Schizophrenia (Heidelb)
Penzel N, Polosecki P, Addington J, Arango C, Asgari-Targhi A, Billah T, Bouix S, Calkins ME, Campbell DE, Cannon TD, Castro E, Cho KIK, Coleman MJ, Corcoran CM, Dwyer D, Frangou S, Fusar-Poli P, Glynn RJ, Haidar A, Harms MP, Jacobs GR, Kambeitz J, Kapur T, Kelly SM, Koutsouleris N, Abhinandan KR, Kucukemiroglu S, Kwon JS, Lewandowski KE, Li QS, Mantua V, Mathalon DH, Mittal VA, Nicholas S, Pandina GJ, Perkins DO, Potter A, Reichenberg A, Reinen J, Sand MS, Seitz-Holland J, Shah JL, Srinivasan V, Srivastava A, Stone WS, Torous J, Vangel MG, Wang J, Wolff P, Yao B, Anticevic A, Wolf DH, Zhu H, Bearden CE, McGorry PD, Nelson B, Kane JM, Woods SW, Kahn RS, Shenton ME, Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), Cecchi G, Pasternak O.   +62 more
europepmc   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

An automated parallel genetic algorithm with parametric adaptation for distributed data analysis. [PDF]

Sci Rep
Al-Terkawi L, Migliavacca M.
europepmc   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Insight into public sentiment and demand in China's public health emergency response: a weibo data analysis. [PDF]

BMC Public Health
Wang Y, Wei M, Wang P, Gao Y, Yu T, Meng N, Liu H, Zhang X, Wang K, Wu Q.   +9 more
europepmc   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

LipidSigR: a R-based solution for integrated lipidomics data analysis and visualization. [PDF]

Bioinform Adv
Liu CH, Shen PC, Tsai MH, Liu HC, Lin WJ, Lai YL, Wang YD, Hung MC, Cheng WC.   +8 more
europepmc   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Identifying key palmitoylation-associated genes in endometriosis through genomic data analysis. [PDF]

BMC Womens Health
Kai J, Su J, You Y, Liang X, Huang H, Fang J, Chen Q.   +6 more
europepmc   +1 more source