Results 41 to 50 of about 9,437,828 (334)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Relationship between income inequality, socioeconomic development, vulnerability index, and maternal mortality in Brazil, 2017

BMC Public Health, 2021
Background Public health recognizes that health conditions depend on factors related to the development patterns income distribution, degree of poverty, working conditions, among other social determinants.
Maria do Socorro Candeira Costa, Francisco Winter dos Santos Figueiredo   +1 more
doaj   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Extreme Gradient Boosting Beats In-Silico Identification of Proteins Potentially Associated With Alzheimer’s

Applied Computational Intelligence and Soft Computing
Alzheimer’s disease (AD) is a chronic, advanced brain sickness disease that slowly destroys memory and thinking skills and, in the end, the ability to perform routine tasks.
Sadia Khalil, Wajid Arshad Abbasi, Syed Ali Abbas, Maryum Bibi, Saiqa Andleeb, Amsa Shabir   +5 more
doaj   +1 more source

Effective connectivity modulations related to win and loss outcomes

NeuroImage, 2020
Previous studies have characterized the brain regions involved in encoding monetary reward and punishment outcomes. The question of how this information is integrated across brain regions has received less attention.
Frederik Van de Steen, Ruth M. Krebs, Nigel Colenbier, Hannes Almgren, Daniele Marinazzo   +4 more
doaj  

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Evaluating the Alignment of a Data Analysis between Analyst and Audience [PDF]

arXiv, 2023
A challenge that data analysts face is building a data analysis that is useful for a given consumer. Previously, we defined a set of principles for describing data analyses that can be used to create a data analysis and to characterize the variation between analyses. Here, we introduce a concept that we call the alignment of a data analysis between the
arxiv  

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

The Dataset Finder: A Tool Utilizing Data Management Plans as a Key to Data Discoverability

Data Science Journal
In the past years, there has been an increased interest in sharing and reusing research data. While the importance of sharing data is urgent for enabling collaboration, many research projects are currently struggling with setting up a strategy and the ...
Soo-Yon Kim, Steffen Hillemacher, Max Kocher, Bernhard Rumpe, Sandra Geisler   +4 more
doaj   +1 more source

Grain - A Java Analysis Framework for Total Data Readout [PDF]

Nucl.Instrum.Meth.A595:637-642,2008, 2007
Grain is a data analysis framework developed to be used with the novel Total Data Readout data acquisition system. In Total Data Readout all the electronics channels are read out asynchronously in singles mode and each data item is timestamped. Event building and analysis has to be done entirely in the software post-processing the data stream.
arxiv   +1 more source