Results 61 to 70 of about 9,437,828 (334)

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

open access: yesFEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra   +7 more
wiley   +1 more source

BFEA: A SAR Ship Detection Model Based on Attention Mechanism and Multiscale Feature Fusion

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
With the advancements in deep learning and synthetic aperture radar (SAR) technology, an increasing number of individuals are utilizing deep-learning techniques to detect ships in SAR images.
Liming Zhou   +4 more
doaj   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

Evaluating the Success of a Data Analysis [PDF]

open access: yesarXiv, 2019
A fundamental problem in the practice and teaching of data science is how to evaluate the quality of a given data analysis, which is different than the evaluation of the science or question underlying the data analysis. Previously, we defined a set of principles for describing data analyses that can be used to create a data analysis and to characterize
arxiv  

Open Data Portal Germany (OPAL) Projektergebnisse [PDF]

open access: yesarXiv, 2021
In the Open Data Portal Germany (OPAL) project, a pipeline of the following data refinement steps has been developed: requirements analysis, data acquisition, analysis, conversion, integration and selection. 800,000 datasets in DCAT format have been produced.
arxiv  

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Elements and Principles for Characterizing Variation between Data Analyses [PDF]

open access: yesarXiv, 2019
The data revolution has led to an increased interest in the practice of data analysis. For a given problem, there can be significant or subtle differences in how a data analyst constructs or creates a data analysis, including differences in the choice of methods, tooling, and workflow.
arxiv  

Declarative data analysis

open access: yesInternational Journal of Data Science and Analytics, 2017
The relational database model constituted a major breakthrough in database technology. It provided a conceptual model for data storage and retrieval that made querying databases much easier. A crucial aspect of this was the introduction of declarative query languages, such as SQL.
openaire   +3 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Disease burden metrics and the innovations of leading pharmaceutical companies: a global and regional comparative study

open access: yesGlobalization and Health, 2020
Background The recent innovation activities of global top-tier pharmaceutical companies in accordance with global and regional health concerns were investigated in order to identify their innovations contributing to population health. Methods “Innovation
Ye Lim Jung, JeeNa Hwang, Hyoung Sun Yoo
doaj   +1 more source

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