Results 101 to 110 of about 6,403,528 (262)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

ExplainedKG-Next: an explainable human mobility pattern learning framework for next location prediction

Geo-spatial Information Science
The sparsity of check-in data significantly impedes the accuracy of location prediction. To address this, various location prediction methods with knowledge graphs have been developed.
Jia Li, Jing Li, Haiyan Liu, Chuanwei Lu, Dewei Zhou, Qingyun Liu   +5 more
doaj   +1 more source

Understanding Health Care Administrators' Data and Information Needs for Decision Making during the COVID-19 Pandemic: A Qualitative Study at an Academic Health System. [PDF]

MDM Policy Pract, 2022
Guerrier C, McDonnell C, Magoc T, Fishe JN, Harle CA.   +4 more
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Military Equipment Entity Extraction Based on Large Language Model

Applied Sciences
The technology of military equipment entity extraction, a crucial component in constructing military knowledge bases, holds significant research value and theoretical importance for guiding the development and improvement of equipment support forces.
Xuhong Liu, Zhipeng Yu, Xiulei Liu, Lin Miao, Tao Yang   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structure-guided decoupled contrastive framework for partial multi-view incomplete multi-label classification

Journal of King Saud University: Computer and Information Sciences
Recently, multi-view multi-label learning has gained significant attention due to its applicability in various domains. However, due to the limitations of data collection and the subjectivity of manual labeling, multi-view multi-label learning often ...
Linqian Yang, Tao Zhuang, Xing Jin, Tianyang Cao, Xiyin Wu   +4 more
doaj   +1 more source

Transforming data to information: A parallel hybrid model for real-time state estimation in lignocellulosic ethanol fermentation. [PDF]

Biotechnol Bioeng, 2021
Cabaneros Lopez P, Udugama IA, Thomsen ST, Roslander C, Junicke H, Iglesias MM, Gernaey KV.   +6 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source