Results 151 to 160 of about 21,724,191 (341)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

GCN and GAT-based interpretable knowledge tracing model

Complex & Intelligent Systems
Knowledge tracing (KT) aims to predict students’ future performance by assessing their level of knowledge mastery from past problem-solving records.
Yujia Huo, Menghong He, Xue Tan, Kesha Chen   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transforming data to information: A parallel hybrid model for real-time state estimation in lignocellulosic ethanol fermentation. [PDF]

Biotechnol Bioeng, 2021
Cabaneros Lopez P, Udugama IA, Thomsen ST, Roslander C, Junicke H, Iglesias MM, Gernaey KV.   +6 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

MODIS information, data and control system (MIDACS) level 2 functional requirements [PDF]

The MODIS Information, Data and Control System (MIDACS) Level 2 Functional Requirements Document establishes the functional requirements for MIDACS and provides a basis for the mutual understanding between the users and the designers of the EosDIS ...
Ardanuy, P., Folta, D., Han, D., Hoyt, D., Jaffin, S., Mckay, A., Ormsby, J., Salomonson, V., Sharts, B., Vallette, B.   +9 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Exploration and Practice of Marine Culture Education and Transmission Path for College Students in Specialized Archives

Haiyang Kaifa yu guanli
Colleges and universities are the key stage of transition connecting schools and society. Since college students are important talents supporting the economic and social development, it is necessary to promote science literacy and awareness among them ...
Baichuan CHEN, Ning LIN, Su WANG, Yuanwei LI   +3 more
doaj  

EmoDNCL+: Dual-stream negative-sample-free contrastive learning with neurophysiological augmentation for EEG emotion recognition

Journal of King Saud University: Computer and Information Sciences
Electroencephalography (EEG) plays a crucial role in emotion recognition, however, its real-world deployment is hindered by generalization limitations due to subject-specific variability and distortions in EEG signals.
Feiyu Jiang, Nisuo Du, Minghao Yu, Qing He   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source