Results 81 to 90 of about 10,212,381 (290)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Trajectory-Based Safety Analysis of Electric Battery Taxis

Journal of Advanced Transportation
This paper utilizes trajectory data of electric taxis in Shenzhen to first study the driving characteristics of electric taxis from different indicators such as travel/driving speed, overspeed ratio, and overspeed amplitude.
Yan Zhuang, Ning Li, Chunjiao Dong, Penghui Li, Bo Xu, Miaoyan Yang   +5 more
doaj   +1 more source

Data assimilation in the low noise regime with application to the Kuroshio

, 2014
On-line data assimilation techniques such as ensemble Kalman filters and particle filters lose accuracy dramatically when presented with an unlikely observation.
Alexander, Apte, Bardi, Chao, Chorin, Chorin, Dembo, Derber, Doucet, Dupuis, Eric Vanden-Eijnden, Evensen, Fleming, Freidlin, Gordon, Heymann, Hunt, Jonathan Weare, Kalman, Karatzas, Kitagawa, Law, Lei, Lewis, Liu, Miller, Miller, Miller, Miyazawa, Nocedal, Ott, Qiu, Stauffer, Taft, van Leeuwen, Vanden-Eijnden, Varadhan, Weare, Weinan, Yang, Yoshida   +40 more
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

A trajectory similarity computation method based on GAT-based transformer and CNN model

Scientific Reports
Trajectory similarity computation is very important for trajectory data mining. It is applied into many trajectory mining tasks, including trajectory clustering, trajectory classification and trajectory search etc.
Liu Dongjiang, Li Leixiao, Li Jie
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Application of data to piloted simulators [PDF]

The application of a further developed analytical model and JAWS data to a piloted simulator is addressed. The Ames simulator provides a facility for the development of piloting procedures, and for the selection of training scenarios.
Bray, Richard S.
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Application of Fast Fourier Transform to Ozone Data at Lagos, Nigeria [PDF]

, 2008
Fast Fourier Transform (FFT) is a mathematical too l often used to represent tim e-varying real data set function /(1). In this paper, the FFT was applied to the measured stratospheric ozone data at Lagos from 1997 to 2002.
Akinyemi, M. L.
core