Results 121 to 130 of about 1,249,061 (355)

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Data archive for the peer-reviewed journal article "Variability in the mass absorption cross-section of black carbon (BC) aerosols is driven by BC internal mixing state at a central European background site (Melpitz, Germany) in winter""

, 2020
Jinfeng Yuan, Robin L. Modini, Marco Zanatta, Andreas Herber, Thomas Mueller, Birgit Wehner, Laurent Poulain, Thomas Tuch, Urs Baltensperger, Martin Gysel‐Beer   +9 more
openalex   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly

Advanced Science, EarlyView.
Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao, Juntao Hu, Juan Du, Shaokun Guo, Youming Hou, Zhihong Li   +5 more
wiley   +1 more source

Finding Hidden Treasures: Investigations in US Astronomical Plate Archives

Acta Polytechnica, 2013
We report here on an ongoing investigation of US astronomical plate archives and tests of the suitability of transportable scanning devices for in situ digitization of archival astronomical plates.
René Hudec, Lukáš Hudec
doaj  

Data Masterthesis Archive

, 2023
This archive contains the Shell script, python scrip, sql scripts, the data base back and the toolchain jar used for the data mining process.
openaire   +1 more source

Archival precipitation data set for the Mississippi River Basin: Algorithm development [PDF]

, 2003
Brian R. Nelson, Witold F. Krajewski, Anton Kruger, James A. Smith, Mary Lynn Baeck   +4 more
openalex   +1 more source

Highly Resolved Community Sewage Metagenomics Unveiling Landscape and Transmission Patterns of Antibiotic Resistome in Hong Kong Populations

Advanced Science, EarlyView.
A large‐scale, high‐resolution antimicrobial resistance (AMR) surveillance in Hong Kong community sewage combining short‐ and long‐read sequencing. The resistome profile is comprehensively characterized, and this upstream sampling strategy demonstrated superiority in reflecting the human gut resistome.
Jiahui Ding, Mengying Wang, Xiaoqing Xu, Dou Wang, Xi Chen, Shuxian Li, Xiawan Zheng, You Che, Yu Deng, Tommy T. Y. Lam, Liguan Li, Tong Zhang   +11 more
wiley   +1 more source

Sociological Data Archives: History and Prospects

RUDN journal of Sociology, 2013
The article examines the history of establishment, principles of organization, areas of activities and missions of the basic national and international archives of sociological research data in Russia, the USA and some European countries.
A T Gasparishvili
doaj  

The open sharing operation mechanism of health data in the digital healthcare era: A study based on grounded theory and interpretative structural modeling method

Digital Health
Objective In the evolving digital healthcare landscape, the strategic exploitation of open health data has become increasingly pivotal. The open sharing of health data is essential due to its irreplaceable role in digital health care. It is made feasible
Xinping Huang, Siyuan Zhu, Zheng Lv, Qianwen Zhou, Tianqi Kou   +4 more
doaj   +1 more source