Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Journal of Electrical and Computer Engineering
doaj +1 more source
Correction: Exploring the potential of nest archives for establishing long-term trends in local populations of an Arctic-nesting colonial sea duck. [PDF]
Álvarez-Manzaneda I +8 more
europepmc +1 more source
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou +19 more
wiley +1 more source
Correction to: Bioactive glass nanoparticles induce strong preferential cytotoxicity and excessive ROS‑mediated oxidative stress and apoptotic genomic DNA damage in non‑small lung cancer cells. [PDF]
Mohamed HRH, Yehia AH.
europepmc +1 more source
Experiences with archived raw diffraction images data: capturing cisplatin after chemical conversion of carboplatin in high salt conditions for a protein crystal [PDF]
S.W.M. Tanley +4 more
openalex +1 more source
Devising affordable and functional linked data archives [PDF]
Balakireva, L +4 more
core +1 more source
Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang +14 more
wiley +1 more source

